Centro Neurolesi Bonino Pulejo

Wearable Inertial Phenotyping of Freezing of Gait in Parkinson’s Disease: Biomechanical Signatures, Subject-Independent Classification, and Clinical Associations

Freezing of gait (FoG) in Parkinson’s disease is clinically heterogeneous, yet wearable-sensor studies predominantly focus on binary FoG detection. We investigated whether right-ankle inertial signals can characterize clinically meaningful FoG manifestations within a three-stage...

Rehabilitation in Pediatric Patients with Acute and Subacute Acquired Brain Injury: A Scoping Review on Non-Pharmacological Interventions

Background: Acquired brain injury in children and adolescents may lead to long-term neurological, cognitive, motor, and behavioral impairments. However, pediatric-specific evidence on rehabilitation strategies remains limited. Objective: This review aimed to summarize current evi...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Effects of deep brain stimulation on functional autonomy and quality of life in Parkinson's disease: A systematic review and meta-analysis

BackgroundDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for advanced Parkinson's disease (PD), primarily targeting motor complications refractory to pharmacological treatment. However, its long-term impact on functional autonomy and quali...

No group-level changes in corticospinal excitability following low-intensity theta-burst ultrasound stimulation of the primary motor hand area

Abstract Low-intensity transcranial ultrasound stimulation (TUS) is a novel non-invasive brain stimulation technique offering high spatial precision and depth penetrance. Theta burst TUS (tbTUS), featuring a temporal theta burst stimulation pattern, has been reported to facilitat...

Bioactivated Glucoraphanin Exerts a Potential Protective Effect in an In Vitro Model of Parkinson’s Disease: A Transcriptomic Study

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Oxidative stress is involved in disease pathogenesis, with the consequent damage to DNA. Nowadays, phytocompounds attract much interest for their capacity to m...

Telerehabilitation for Motor Recovery in Adults with Neurological Disorders: A Systematic Review and Meta-Analysis Across Motor Domains, Delivery Models, and Follow-Up Effects

Background/Objectives: Telerehabilitation may extend neurorehabilitation beyond conventional settings, but comparative effects across neurological diagnoses and motor domains remain uncertain. This systematic review and meta-analysis synthesized motor outcomes while distinguishin...

Chronological Age and Adaptive Outcomes Following Neuropsychomotor and Aquatic Interventions in Children with Autism: A Secondary Analysis

Background: Autism Spectrum Disorder (ASD) can be conceptualized not as a static condition but as a dynamic disorder of developmental regulation, in which neuroplastic potential is translated into functional gains only through structured, experience-dependent therapeutic input. N...

Decoding Synaptic Diversity: Molecular Architectures, Phase Transitions, and Shared Postsynaptic Failure in Alzheimer’s and Parkinson’s Disease

Synaptic failure is the most accurate pathological correlate of cognitive and motor decline in neurodegenerative diseases. However, the molecular logic governing selective synaptic vulnerability in Alzheimer’s (AD) and Parkinson’s (PD) remains a fundamental enigma. This review di...

Depressive symptom trajectories after spinal cord injury: a secondary analysis of public-use data

Background Depressive symptoms after spinal cord injury (SCI) are linked with poorer participation and greater health service use, but long-term symptom heterogeneity remains incompletely defined. Objective: To identify model-based depressive symptom trajectories after SCI and ex...