Centro de Investigacion Principe Felipe

Data-driven identification of small molecules inducing brown adipocyte activation and differentiation

Promoting the recruitment and function of human brown adipose tissue (BAT) holds significant promise for preventing and treating obesity and related metabolic complications. While identifying genes to enhance BAT recruitment and thermogenic activation is crucial, traditional upre...

DisMed-LLM: De-Identifying Spanish Medical Text with Large Language Models

Abstract Patient privacy and compliance with regulations such as the General Data Protection Regulation (GDPR) necessitate the robust de-identification of clinical texts. This study investigates the feasibility, computational cost, and limitations of de-identifying Spanish medica...

Drug Permeation Dataset Across Diverse Chemical Space Using PermeaPad and High-Throughput Plate Reader Assays

Abstract Purpose High-throughput permeation assays are essential tools in drug discovery for identifying small molecules with favorable permeability, yet quantifying their transport kinetics across biomimetic membranes often relies on resource-intensive chromatographic methods. H...

Integrated multiomics analysis reveals metabolic and microbiome alterations in Wilson disease

Wilson disease (WD) is a rare autosomal recessive disorder caused by mutations in ATP7B , which encodes a copper transporter. Abnormal ATP7B function leads to copper deposition, mainly in the liver and brain, resulting in hepatic, neurological, and psychiatric impairments. Metabo...