Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Dissecting Binary and Ternary Iminoboronate Assemblies: A Calorimetric Study of Thermodynamics, Kinetics, and Allosteric Effects

Abstract Dynamic covalent assemblies derived from ortho-boronoaldehydes, including iminoboronates and boronate esters, are key structural motifs in adaptive materials, chemical sensors, and reversible bioconjugation strategies. Herein, we report a label-free assay based on isothe...

Western diet induces MASLD and major transcriptional reprogramming in the liver-gut axis of early zebrafish larvae

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to western diet and sedentary lifestyle. While larval zebrafish are powerful discovery tools, standardized diets inducing early-stage MASLD are lacking. Here, we developed and early-stage zebrafis...

Emergency Department-Based Screening and Linkage-to-Care for Hepatitis B, C, and D in a Referral Hospital in Barcelona, Spain: Reduction in Hepatitis C Prevalence After Five Years

Background: Emergency Department (ED) viral hepatitis screening programs typically report short-term outcomes. We evaluated the medium-term impact of an ED-based screening for Hepatitis C (HCV), Hepatitis B (HBV), and Hepatitis D (HDV) viruses. Methods: Prospective opportunistic...

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug-induced liver injury (DILI) is still scarce. We aimed to ascertain the incidence, clinical profile, culprit drugs, and prognosis associated with concomitant DILI and AKI. We include patients from two long-...

BioFRAM PGx, an Implementation Proposal for Pharmacogenetics in the Spanish National Health System

Background/Objectives: Pharmacogenetics (PGx) may improve drug safety and effectiveness, but its integration into routine care remains heterogeneous across the Spanish National Health System (NHS). This article presents BioFRAM PGx, a multicentre implementation framework that def...

Integrated multiomics analysis reveals metabolic and microbiome alterations in Wilson disease

Wilson disease (WD) is a rare autosomal recessive disorder caused by mutations in ATP7B , which encodes a copper transporter. Abnormal ATP7B function leads to copper deposition, mainly in the liver and brain, resulting in hepatic, neurological, and psychiatric impairments. Metabo...

Multifactorial ecological framework for intestinal-type gastric cancer

Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, with projections indicating increasing incidence and marked geographic variability across populations. Although multiple hypotheses have been proposed to explain this heterogeneity, inclu...

MicroRNAs and Other Small RNAs in Liquid Biopsies as Biomarkers for Early Detection of Colorectal Cancer

Early detection of colorectal cancer (CRC) is a major determinant of patient prognosis, as survival strongly depends on disease stage at diagnosis. Despite advances in screening programs, a significant proportion of CRC cases are still diagnosed at advanced stages, underscoring t...

Colorectal Cancer Mortality Following an Organized Fecal Immunochemical Test–Based Screening Program

Importance Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Organized screening programs using the fecal immunochemical test (FIT) have been implemented to reduce CRC mortality through early detection. Objectives To evaluate the association betwee...