Centro de Investigación Biomédica en Red

Effects of a Chilean Hazelnut-Supplemented Diet on Oxidative Stress and Cytokine Expression in PBMCs of Hypercholesterolemic Adults: A Randomized Controlled Trial

Background/Objectives: Hypercholesterolemia is characterized by alterations in lipid metabolism, oxidative stress, and inflammatory status. Nuts have been shown to mitigate these alterations; however, limited evidence is available regarding their effects in the Chilean population...

Early‐Life Betaine Supplementation Drives Sex‐Specific Metabolic Programming in Rats, Affecting FGF21 Signaling and Energy Balance

ABSTRACT We aimed to evaluate the effects of maternal diet and betaine supplementation during the suckling period on Fgf21 expression and metabolic pathways related to FGF21 signaling and metabolic programming. Offspring of Wistar rats fed either a chow diet (CD) or a Western die...

Sex-related differences in clinical characteristics, management, and outcomes of Enterococcus faecalis bloodstream infection

OBJECTIVES: To evaluate whether clinical characteristics and outcomes of patients with Enterococcus faecalis bloodstream infection (EF-BSI) differ by biological sex. METHODS: Quasi-experimental study conducted at two hospitals, comprising a retrospective phase (2017-2019) and a p...

Convolutional Neural Networks for Sleep Apnea Detection from Electrocardiographic Signals

Background: Obstructive sleep apnea (OSA) is a highly prevalent chronic respiratory disorder with important consequences for cardiovascular health and quality of life. Its often non-specific clinical presentation contributes to substantial underdiagnosis, while the logistical, te...

In Situ Analysis of Chiral Gold Nanorod Growth by Nanofluidic Liquid-Phase Electron Microscopy

Abstract Chiral gold nanoparticles exhibit unique chiroptical properties, but their integration into plasmonic devices requires an understanding of the formation of chiral features and controlling their growth on substrates. Here, we combine microfluidic synthesis and liquid-phas...

From Platform Development to Scale-Up: Stable Producer Cell Line-Based Lentiviral Vector Manufacturing

Background: The development of stable producer cell lines (SCLs) represents a promising alternative for lentiviral vector (LVV) manufacturing, offering improved reproducibility and reduced manufacturing costs. In previous work, our group established an SCL generation platform bas...

Capillin, a Polyacetylene from Argyranthemum frutescens, a Promising Hit Compound for Antikinetoplastid Drug Discovery

Chagas disease and leishmaniasis, caused by the protozoan Trypanosoma cruzi and different Leishmania species, respectively, remain public health problems in developing regions due to high prevalence and the limited efficacy and safety of current treatments. Plant-derived natural...

A phosphoproteome atlas of human cell lines reveals the landscape of kinase activity

Abstract Protein phosphorylation orchestrates cellular signaling and controls most biological processes, with its dysregulation driving diseases, notably cancer. Comprehensive, high-throughput phosphoproteomics remains limited by detection sensitivity, data completeness and compu...

Cardio-Oncological Sequelae of Autologous Stem Cell Transplantation

Autologous hematopoietic stem cell transplantation is a major milestone in modern oncohematological therapies; however, both in the peritransplant and post-transplant phase, the incidence of cardiovascular (CV) events is markedly higher than in the general population. The pathome...

HIV-1 Drug Resistance in Mother–Infant Pairs in Southern Mozambique

This prospective nested cohort (EARTH) study evaluated drug resistance mutations and outcomes among 79 (31 with genetic results) early-treated Mozambican children living with HIV, followed for 50 months. Mortality reached 20.3%. Drug resistance mutations were detected in 58.1% of...

Scaling of an evidence-based intervention program in older people with diabetes and frailty in Latin America. Diabfrail-Latam clinical trial protocol

Objectives Diabfrail-Latam is a project funded by the Horizon 2020 program of the European Commission (EC) and the Global Alliance for Chronic Diseases (GACD). The main objective of this protocol is to describe the clinical validation of a multimodal intervention aimed at older p...

Diet quality and environmental sustainability: integrating dietary indices and planetary impacts

Dietary patterns are major determinants of nutritional status and environmental sustainability. Despite growing interest in sustainable diets, limited research has examined how dietary carbon footprints differ across age groups and how age-specific dietary behaviors interact with...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

Baseline Ferritin and Body Composition as Correlates of Longitudinal Metabolic Changes During an Energy-Restricted Mediterranean-Style Intervention Across Three Overweight Phlogistic-Related Clinical Conditions

Background/Objectives: Chronic inflammation accompanies obesity, but correlations of longitudinal changes during dietary follow-up remain unclear. We described inflammatory profiles and examined associations of baseline ferritin and body composition with changes during a 32-week...

Associations Between Chocolate Consumption and Cardiometabolic Risk Markers Across Metabolic Profiles: Insights from a Population-Based Study

Background/Objectives: Studies evaluating the association between chocolate consumption and cardiometabolic health have reported inconsistent findings, and whether these associations differ according to underlying metabolic status remains unclear. This cross-sectional study analy...

Alcohol consumption and cardiovascular health: balancing assumed benefits with the available evidence

1. The distinction between the well-established harms of high total alcohol intake versus purported cardiovascular benefits of small amounts of wine seems crucial [1–3]. Ethanol at high doses is a ...

Anatomical Determinants of the Left Atrial Electrograms: Wall Thickness and Myocardial Fat Infiltration

INTRODUCTION: Electrogram peak-to-peak voltage depends on atrial wall structure and mapping configuration. We evaluated the relationship between computed tomography-derived atrial wall thickness, intramyocardial fat, myocardial muscle thickness, and electrogram voltage obtained w...

Plasma Aβ42/Aβ40 predicts longitudinal amyloid pathology and clinical progression in amyloid-PET negative individuals with subjective cognitive decline

Early detection of amyloid-β (Aβ) pathology is critical for timely intervention in Alzheimer’s disease (AD). Changes in plasma Aβ42/Aβ40 levels appear early in the AD continuum, but whether they precede amyloid deposition detected by Aβ-PET requires further research. Data from 16...

Adaptation and Usability of a Lifestyle Cancer Prevention Screener for US Populations: A Mixed Methods Study

Abstract Background: The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Cancer Prevention Recommendations provide evidence-based guidance on modifiable lifestyle factors associated with cancer risk. While a standardized scoring system exists to asse...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...