Centro Científico Tecnológico - Tucumán

BDF6 Deficiency Severely Compromises Intracellular Amastigote Development and Infectivity of Trypanosoma cruzi

Abstract Trypanosoma cruzi, the causative agent of Chagas disease, relies on complex gene regulatory mechanisms to adapt to its diverse host environments. In recent years, it has been established that epigenetics plays an essential role in these mechanisms via the regulation of c...

Koolen‐de Vries syndrome: Epilepsy‐associated features in a patient with a novel likely pathogenic KANSL1 single‐nucleotide variant

The authors declare no conflicts of interest. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Data S1: Educational_slides. Data S2: Test_Yourself_A...

Tailoring Reactivity of Molecular Gallium Hydroxides via Chalcogen Bridging

Abstract We studied the influence of bridging chalcogen atoms (μ-E; E = S, Se) on the structure and reactivity of digallium dihydroxide complexes [{MeLGa(OH)}2(μ-E)] [E = S (4), Se (5); MeL = CH{CMe(NAr)}2–, Ar = 2,4,6-Me3C6H2]. Compounds 4 and 5 were synthesized from MeLGaCl2 an...

Acquired hemophilia: insights from a multicenter real-life study in a middle-income country

Background Acquired hemophilia A (AHA) is a rare hemorrhagic disease with scarce published information from developing countries. Objectives The main objective was to describe the clinical manifestation and treatment, as well as laboratory characteristics of patients with AHA. Pa...

Order–disorder interfaces in viral pRb inactivation: molecular dynamics insights into SLiM-mediated recognition and implications for interaction databases

Intrinsically disordered regions (IDRs) mediate protein interactions through poorly understood mechanisms. We studied the retinoblastoma protein (pRb) and its interaction with the SV40 Large T antigen (LTSV40), a viral oncoprotein that displaces E2F factors. Using molecular dynam...

Order–disorder interfaces in viral pRb inactivation: molecular dynamics insights into SLiM-mediated recognition and implications for interaction databases

Intrinsically disordered regions (IDRs) mediate protein interactions through poorly understood mechanisms. We studied the retinoblastoma protein (pRb) and its interaction with the SV40 Large T antigen (LTSV40), a viral oncoprotein that displaces E2F factors. Using molecular dynam...

A micronova burst in the intermediate polar IGR J17014-4306

Abstract We report the detection of a short optical burst in TESS data of IGR J17014-4306, the eclipsing intermediate polar with the longest known orbital period. The burst lasts 1.56 d and shows multiple peaks, reaching (9.3 ± 0.2) × 1033 erg s−1, and releases a total energy of...

Agricultura Familiar y Agroindustrias: subordinación productiva. Los casos de la citricultura y la fruticultura de Argentina (2003-2016)

This article proposes to investigate the link between family farming (AF) and agro-industries. The research is based on a qualitative methodology and uses quantitative information. In particular, two cases (citric belt of Middle Uruguay River and fruit growing of Patagonic Valley...

Adolescents’ Emotional Intelligence and Self-Perception in the Context of Social Media Use

This study examined the relationships between perceived emotional intelligence (EI), self-esteem, self-concept, and social media use in a sample of 173 Argentinian adolescents (mean age 16.6). Using the TMMS to assess three EI dimensions (attention, clarity, and mood repair) alon...