Centro Científico Tecnológico - San Juan

Benchmarking control strategies for wave energy converters: From idealised knowledge to realistic operation

Maximising energy extraction in wave energy converters remains challenging due to the non-causal nature of the optimal control, complex interactions and real-time constraints. This paper presents a benchmarking of four strategies: LiTe-Con, LiTe-Con+, model predictive control (MP...

CNS distribution and preclinical activity of the PI3K/AKT inhibitors inavolisib and ipatasertib in pediatric-type diffuse high-grade gliomas

Abstract Purpose Pediatric-type diffuse high-grade gliomas (pHGG) are aggressive, largely incurable malignancies often characterized by PI3K/AKT pathway activation. This study investigated whether the PI3K inhibitor inavolisib and the AKT inhibitor ipatasertib could achieve thera...

Satellite telemetry suggests significant regional variation in post-fledging survival of Adélie penguins

Abstract Post-fledging periods represent one of the most vulnerable stages for juvenile seabirds. Adélie penguins Pygoscelis adeliae must quickly develop foraging skills while minimizing predation risk immediately after fledging. In the Antarctic Peninsula (AP) region, where popu...

Core protein mutations are key determinants of hepatitis B virus replication during the hepatitis B e antigen-negative stage

The natural history of chronic hepatitis B virus (HBV) infection comprises distinct stages resulting from virus–host interactions. A late and pivotal event in this process is hepatitis B e antigen (HBeAg) seroconversion, marked by the abrogation of HBeAg expression, a significant...

Bacterial Communities Associated with Deschampsia antarctica in Chronically Diesel-Contaminated Soils: Candidate Taxa for Microbe-Assisted Phytoremediation

More than six decades of human activity in Antarctica resulted in chronic diesel contamination of soils surrounding research stations. Phytoremediation assisted by the native vascular plant Deschampsia antarctica is one of the few remediation strategies compatible with the Antarc...

Soil physical quality and organic carbon in agricultural systems of the Dry Chaco: influence of land use intensity and predictive models

Context The expansion of the agricultural frontier in northwestern Argentina occurred at the expense of deforestation of native forests, particularly in the Dry Chaco. This land-use change alters soil physical properties and soil organic carbon (SOC), compromising sustainability....

Prioritization of chemical scaffolds using the TDR Targets database: An integrative workflow for Trypanosoma cruzi drug discovery

Abstract Chagas disease, caused by the parasite Trypanosoma cruzi , faces a critical innovation gap in drug development, with current treatments hindered by toxicity and limited efficacy. To address this, we implemented an integrative chemogenomic workflow using the TDR Targets d...