Centro Científico Tecnológico - San Juan

Systematic genome analysis enables long-overdue taxonomic reorganization of genus Orthoflavivirus; potential assignment of over 50 new species

Members of the Orthoflavivirus genus in the family Flaviviridae are primarily vector-transmitted RNA viruses infecting humans, other mammals and birds, including major pathogens such as tick borne encephalitis, West Nile, Zika and dengue viruses. Vector-borne flaviviruses are ass...

Impact of an Extra Virgin Olive Oil-enriched Diet in Diabetic Dams on the Decidua of offspring Prone to Gestational Diabetes

Background During early pregnancy, the decidua supports embryo development and maternal adaptations to pregnancy. Maternal diabetes programs gestational diabetes mellitus (GDM) in offspring, and a pro-oxidant intrauterine environment has been implicated. Diets enriched with extra...

Weaker Coherence, Weaker Reciprocity: Comparing the Semantic and Social Organization of Moltbook and Reddit

Large language models enable the creation of autonomous agents that interact in social environments, raising the question of whether agent-based platforms reproduce the organizational properties of human social networks. We compare Moltbook, a social network populated by AI agent...

Mannose-Functionalized Polymeric Micelles Target CD206-Expressing Macrophages Within Human Tuberculosis Granulomas and Improve Isoniazid Delivery

Background: Latent tuberculosis infection (LTBI) remains a global health challenge, in part due to the ability of Mycobacterium tuberculosis (Mtb) to persist within granulomatous lesions where drug exposure may be limited. Because granulomas are heterogeneous structures composed...

BDF6 Deficiency Severely Compromises Intracellular Amastigote Development and Infectivity of Trypanosoma cruzi

Abstract Trypanosoma cruzi, the causative agent of Chagas disease, relies on complex gene regulatory mechanisms to adapt to its diverse host environments. In recent years, it has been established that epigenetics plays an essential role in these mechanisms via the regulation of c...

Benchmarking control strategies for wave energy converters: From idealised knowledge to realistic operation

Maximising energy extraction in wave energy converters remains challenging due to the non-causal nature of the optimal control, complex interactions and real-time constraints. This paper presents a benchmarking of four strategies: LiTe-Con, LiTe-Con+, model predictive control (MP...

CNS distribution and preclinical activity of the PI3K/AKT inhibitors inavolisib and ipatasertib in pediatric-type diffuse high-grade gliomas

Abstract Purpose Pediatric-type diffuse high-grade gliomas (pHGG) are aggressive, largely incurable malignancies often characterized by PI3K/AKT pathway activation. This study investigated whether the PI3K inhibitor inavolisib and the AKT inhibitor ipatasertib could achieve thera...

Satellite telemetry suggests significant regional variation in post-fledging survival of Adélie penguins

Abstract Post-fledging periods represent one of the most vulnerable stages for juvenile seabirds. Adélie penguins Pygoscelis adeliae must quickly develop foraging skills while minimizing predation risk immediately after fledging. In the Antarctic Peninsula (AP) region, where popu...

Core protein mutations are key determinants of hepatitis B virus replication during the hepatitis B e antigen-negative stage

The natural history of chronic hepatitis B virus (HBV) infection comprises distinct stages resulting from virus–host interactions. A late and pivotal event in this process is hepatitis B e antigen (HBeAg) seroconversion, marked by the abrogation of HBeAg expression, a significant...

Bacterial Communities Associated with Deschampsia antarctica in Chronically Diesel-Contaminated Soils: Candidate Taxa for Microbe-Assisted Phytoremediation

More than six decades of human activity in Antarctica resulted in chronic diesel contamination of soils surrounding research stations. Phytoremediation assisted by the native vascular plant Deschampsia antarctica is one of the few remediation strategies compatible with the Antarc...

Soil physical quality and organic carbon in agricultural systems of the Dry Chaco: influence of land use intensity and predictive models

Context The expansion of the agricultural frontier in northwestern Argentina occurred at the expense of deforestation of native forests, particularly in the Dry Chaco. This land-use change alters soil physical properties and soil organic carbon (SOC), compromising sustainability....

Prioritization of chemical scaffolds using the TDR Targets database: An integrative workflow for Trypanosoma cruzi drug discovery

Abstract Chagas disease, caused by the parasite Trypanosoma cruzi , faces a critical innovation gap in drug development, with current treatments hindered by toxicity and limited efficacy. To address this, we implemented an integrative chemogenomic workflow using the TDR Targets d...