Centro Andaluz de Biología del Desarrollo

Use of Tamoxifen Derivatives in Combination with Colistin against Colistin-Resistant Acinetobacter baumannii

Abstract Drug repurposing has led to the identification of tamoxifen, a well-known chemotherapy drug, as a compound with relevant antibacterial properties. In this field, the development of new tamoxifen derivatives with antimicrobial activity, particularly against colistin-resis...

Mules in the Antiquity of Southern Iberia revealed from proteomics

The management of equids in the Iberian Peninsula during the Iron Age (first millennium BCE) provides a key archaeological context for investigating the emerging stages of confluent breeding of horses ( Equus caballus ) and donkeys ( Equus asinus ). This scenario provided the ear...

Protein Language Model Embeddings Recover Evolutionary and Functional Organization Across the Ras Superfamily

Abstract The Ras protein superfamily comprises small GTPases that share a conserved G-domain but differ in flanking regions, regulation, and cellular roles. Because existing classifications rely mainly on G-domain phylogeny, this superfamily provides a useful test case for assess...

Domain-combination based pan-genomic tree of life

Abstract Reconstructing the Tree of Life (ToL) remains a central challenge in evolutionary biology. While sequence-based methods have resolved much of life’s diversity, deep evolutionary relationships often remain elusive, particularly across the three superkingdoms of life. Here...

Mitochondrial aggregates as a novel quality control mechanism and potential relationship to lipofuscinogenesis

Mitochondria employ quality control mechanisms to maintain homeostasis. Under chronic stress, these systems become overwhelmed, causing intramitochondrial aggregates formation. As a potential quality control process when canonical pathways are compromised, we propose a model of m...