Centre of Experimental Medicine of the Slovak Academy of Sciences

In vivo DNA damage protection during cell migration across confining embryonic tissue environments

Abstract Cells migrating through confined spaces can experience nuclear deformation, nuclear envelope damage and DNA lesions, but the physiological consequences of confinement in vivo remain unclear. Using the zebrafish neural crest as a model of developmental migration, we show...

Natural Bioactive Compounds in Rheumatoid Arthritis: Experimental Evidence from Adjuvant Arthritis Model Supporting Combination Strategies with Methotrexate

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that represents continuous synovial inflammation, oxidative stress, immune dysregulation, and progressive cartilage degradation and bone erosion. Although disease-modifying antirheumatic drugs (DMARDs), includ...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Defining ‘psychedelic’

Humphry Osmond coined the term ‘psychedelic’ in 1956, conjoining ‘psyche’ for ‘soul’ and ‘delic’ for ‘to manifest’ or ‘illuminate’. Soul-illumination is a compound noun that describes a psychological state or process. Osmond intended for it to be a taxonomic noun—naming, not just...

From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation

The persistent shortage of human organs for transplantation has intensified efforts to develop alternative sources, specifically xenotransplantation and exogenesis. Xenotransplantation uses genetically engineered pigs to provide organs, tissues, and cells for clinical use. Signif...