Centre Interdisciplinaire de Recherche en Biologie

Routing to the seizure in postoperative human glioma cortex: spatio-temporal uncoupling between slow and fast extracellular neuronal activities

Abstract Background Diffuse gliomas are frequently associated with epilepsy, particularly in low-grade variants. Seizures are key events to be considered in glioma management, including during surgery. Optimizing resection of epileptic areas may affect not only postoperative epil...

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Embryos resolve the enigmatic origin of the theropod wishbone

The origin of the avian wishbone (furcula)—present since theropod dinosaurs—remains unsolved. Its homology is still debated, with competing hypotheses proposing derivation from the clavicles, the interclavicle, or both. To obtain comparative developmental evidence, we studied oss...

Computational identification and experimental validation of early glycinergic impairments in spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disorder characterized by lower motor neuron (MN) loss, due to mutations or deletions in the Survival Motor Neuron 1 ( SMN1 ) gene. Increasing evidence implies mitochondrial dysfunctions in SMA, suggesting these org...