Centre Hospitalier Universitaire Sainte-Justine

Elevated prenatal IL-6 levels disrupt early patterns of hippocampal electrical activity and chloride homeostasis by targeting GABAergic signaling at perinatal stage

Abstract Early patterns of neuronal electrical activity are fundamental for driving critical developmental processes, including neuronal maturation and synapse formation. While genetic programs are key in orchestrating these events, the influence of environmental stressors remain...

Early Pregnancy Use of Anti-CGRP Monoclonal Antibodies and Propranolol and Spontaneous Abortion Risk

Importance Migraine affects individuals of reproductive age, but treatment options during pregnancy are limited due to safety concerns. Anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) are effective for migraine prevention; however, CGRP is important in pl...

Consented Universal Newborn Screening for Congenital Cytomegalovirus Infection Using Dried Blood Spot and Dried Saliva Spot Specimens: Implementation and Relative Programmatic Accuracy

The purpose of this research was to evaluate the implementation and relative diagnostic accuracy of dried blood spot (DBS) and dried saliva spot (DSS)-based newborn screening for congenital cytomegalovirus infection (cCMV). This prospective paired-sample pilot studied consecutive...

Lateral Extra-articular Tenodesis Does Not Alter Early Gait Biomechanics After ACL Reconstruction in a Pediatric Population: A Motion Analysis Study

Background: Lateral extra-articular tenodesis (LET) is increasingly added to anterior cruciate ligament reconstruction (ACLR) to reduce graft failure and improve rotatory stability. However, concerns remain that LET may overconstrain the lateral compartment, alter gait biomechani...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Medication use during pregnancy in Europe and North America: a systematic review

To describe the mean number of medications used as well as the prevalence of medication use throughout pregnancy in Europe and North America, with a focus on use by trimester, type of medication, and use of harmful medications. A systematic review was performed searching MEDLINE,...

Guideline adherence of antibiotic prescriptions for urinary tract infections in a pediatric emergency department: a retrospective cohort study

Antimicrobial resistance (AMR) is a significant challenge. Adherence to data-driven local guidelines ensures effective treatment and limits AMR. Urinary tract infections (UTIs) in children are common and choices of empirical treatments represent an interesting opportunity for ant...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Determinants of complementary feeding practices – a qualitative study exploring mothers and fathers’ experiences in Canada

The complementary feeding period, defined as the introduction of solid foods alongside continued breastmilk and/or infant formula, is increasingly recognized as a critical window of opportunity for the healthy development of children. However, parental adherence to complementary...

Respiratory Syncytial Virus–Related Hospitalizations Among Infants Receiving Nirsevimab

Importance Respiratory syncytial virus (RSV) is a leading cause of hospitalization among infants. Nirsevimab, a long-acting monoclonal antibody that protects against severe RSV, was publicly funded for all infants in the Canadian provinces of Ontario and Quebec starting in the fa...

Pediatric Epiglottopexy: A Scoping Review of Indications, Techniques, Outcomes, and Complications

ABSTRACT Objective To map and synthesize the evidence on epiglottopexy in pediatric patients with laryngomalacia, epiglottic prolapse, and obstructive sleep apnea (OSA) with attention to indications, techniques, outcomes, complications, and evidence gaps. Data Sources PubMed/MEDL...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Sex-related and postnatal development of the glutathione antioxidant system in extremely preterm infants: laboratory findings from a randomized controlled trial

Preterm birth disrupts in utero antioxidant system maturation, including glutathione metabolism, and forces infants’ transition to a relatively oxidative extrauterine environment, leading to multiple devastating complications. This study aims to describe sex-related differences a...

Prevalence and Characteristics of Mental Health Interventions Following Pediatric Hospitalization

BACKGROUND AND OBJECTIVES: As survival after pediatric critical illness improves, attention has shifted to post-intensive care syndrome and the long-term mental health of pediatric intensive care unit (PICU) survivors, who have high rates of posttraumatic stress, anxiety, and dep...

Uncovering scleromyositis: no myth, just missed

Purpose of review Scleromyositis (SM), the muscle-specific manifestation of scleroderma, is increasingly recognized as a distinct myositis subset, yet it remains poorly captured by existing classification criteria and absent from therapeutic guidelines. This review provides recen...

Postoperative Interventions and Cost Associated With Disposition After Tonsil and Adenoidectomy

OBJECTIVE To evaluate postoperative disposition and resource use among patients admitted to the inpatient unit or pediatric intensive care unit (PICU) following tonsillectomy, adenoidectomy, and tonsillectomy/adenoidectomy (T/A). PATIENTS AND METHODS This retrospective cohort stu...

The Association Between Intranasal Steroids and Length of Stay in Children With Orbital Infections

OBJECTIVE: Little is known about the use of intranasal agents in the management of orbital infections in children. This study aims to describe intranasal corticosteroid use in children hospitalized with orbital infections and to determine whether an association exists between int...

Understanding Caregivers’ Experiences of Rett Syndrome: A Multinational Study of Symptoms and Meaningful Outcomes of Potential Treatments

Caregivers have first-hand experience of facing the daily challenges of Rett syndrome (RTT). The aim of this study was to understand caregivers’ experiences of RTT, including challenging symptoms that caregivers hope novel therapies will address. This non-interventional, qualitat...

IgG4-Related Skin Disease in a 9-Year-Old Patient: Remission Under Mycophenolate Mofetil After Rituximab Failure

Background IgG4 related disease (IgG4-RD) is a systemic immune-mediated disease characterized by inflammation and fibrosis of nearly any organ.[1] This condition is rarely reported in children and especially with cutaneous involvement. We report the case of IgG4 related disease i...