Centre Hospitalier Universitaire de Sherbrooke

The impact of physical activity and exercise timing on metabolic health among individuals at high risk of type 2 diabetes

The timing of physical activity and exercise has been suggested to play a role in metabolic health. This narrative review synthesises current evidence on the impact of habitual physical activity and exercise timing on glucose homeostasis and insulin sensitivity, blood lipids and...

Ethical guidance for randomized controlled trials of donor interventions in deceased organ donation: a scoping review of international guidelines, consensus statements, and expert recommendations

Deceased donor interventions are nontherapeutic interventions to improve the likelihood of successful donation and transplant outcomes. Randomized controlled trials (RCTs) could strengthen the evidence base for donor interventions, but such trials face difficult ethical challenge...

The apelinergic system accelerates wound healing in both type 1 and 2 diabetic mice

Chronic wounds are a serious complication of diabetes. Multiple components in the healing process are impaired by diabetes, creating hard-to-heal or non-healing wounds, and increasing the risk of infection, enlargement, and amputation. Altered angiogenesis is a major contributor...

Exploration of Physiotherapists' Understanding and Application of Safety Netting Procedures in France—A Qualitative Study

BACKGROUND: Physiotherapists in primary care frequently manage patients with musculoskeletal disorders that may conceal serious underlying pathologies, leading to diagnostic uncertainty. Although safety netting is recommended to enhance diagnostic reasoning and ensure patient saf...

Dr. Tsai et al reply

We appreciate the interest of Drs. Wang and Qu¹ in our work,² and their call for more family-friendly metrics to help convey meaningful quality of life improvements in juvenile idiopathic arthritis ( JIA). After considering the different ideas suggested in t...

SDHC c.397C>T- Related Pheochromocytomas and Paragangliomas: Insights from an International Study

BACKGROUND: The SDHC c.397C>T (p.Arg133Ter) germline pathogenic variant is present in over 40% of mutation-positive paragangliomas in French-Canadian patients, supporting a founder effect. We aimed to characterize pheochromocytomas and paragangliomas (PPGLs) associated with this...