Centre Hospitalier Universitaire de Saint-Pierre

Pharmacokinetic Modeling and Dosing Simulations of Temocillin in Children With Urinary Tract Infections

Background: Temocillin, active against most extended-spectrum β-lactamases (ESBL)-producing Enterobacterales , is increasingly considered a carbapenem-sparing option for Gram-negative infections. Despite a recommended pediatric dose of 25–50 mg/kg/d in 2 administrations, its phar...

Premedication practices prior to neonatal laryngoscopy: a nationwide observational study in Belgian NICUs

Intubation or less invasive surfactant administration (LISA) in neonates both require laryngoscopy, a stressful and painful procedure. This study aimed to document premedication practices before laryngoscopy in Belgium and explore reasons for absence of premedication. Sub-analysi...

Lobular cancerization in biopsy-diagnosed ductal carcinoma in situ (DCIS) of the breast: a detailed histopathological evaluation and reproducibility study

The role of lobular cancerization in ductal carcinoma in situ (DCIS) of the breast is poorly described to date. A precise definition is lacking. We explored the association between lobular cancerization in biopsy-diagnosed DCIS and different other histopathological features, as w...

Safety and Performance of the Colovac Anastomosis Protection Device. A Pooled Analysis of Prospective Studies Compared With Diverting Loop Ileostomy (SAFE-2025)

Objective: To compare the safety and effectiveness of the Colovac Anastomosis Protection Device with standard diverting ostomy (DO) following low anterior resection (LAR) for rectal cancer. Summary Background Data: DO is standard of care (SOC) following LAR for rectal cancer but...