Centre Hospitalier Universitaire de Nice

Can machine learning be used to quantify blood loss based on hemodynamic data? Experimental study of controlled hemorrhagic shock in anesthetized piglets

Background Hemorrhagic compensatory physiological mechanisms may initially lead to an underestimation of the severity of a hemorrhage, for which quantification of blood lost volume is difficult. The objective of our study was to assess the suitability of machine learning (ML) to...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Opioid use, disability, and patient‐reported cognitive impairment in migraine: Multi‐country results from the Chronic Migraine Epidemiology and Outcomes—International Study

OBJECTIVE: To characterize the population who do and do not use opioids to treat migraine in the Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) Study. BACKGROUND: Opioids are not recommended for migraine treatment because of efficacy and safety limitations. ME...

Interest of luspatercept in treatment of anemia in lower-risk of myelodysplastic syndrome anemia: a single center study of 26 patients

Myelodysplastic syndromes (MDS) are heterogeneous clonal hematological disorders characterized by ineffective hematopoiesis resulting in peripheral cytopenias. Luspatercept, an erythroid maturation agent, represents a novel therapeutic option for the management of anemia associat...

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

BACKGROUND: Mogamulizumab, an anti-CCR4 monoclonal antibody used in advanced mycosis fungoides (MF) and Sezary syndrome (SS), also depletes regulatory T cells, potentially leading to immune-related adverse events (irAEs). Unlike mogamulizumab-associated rash (MAR), other irAEs re...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Early systemic intervention for vitiligo: A prospective bicentric interventional study

BACKGROUND: Vitiligo is a complex autoimmune skin disease characterized by loss of melanocytes resulting in the appearance of white skin patches. Recent advances in treatment have improved patient outcomes, but the process of repigmentation is prolonged and often incomplete. OBJE...

Low intensity transcranial electrical stimulation for schizophrenia: a triple-blind, randomized, sham-controlled multicenter trial (STIM’Zo)

Persistent symptoms in schizophrenia remain a major therapeutic challenge. Noninvasive electrical stimulation such as transcranial random noise stimulation (tRNS) may alleviate auditory hallucinations and negative symptoms, although existing evidence is limited to case reports an...

Ultrasensitive multiplex salivary cytokine profiling reveals distinct immune signatures in dental caries

Dental caries is a prevalent chronic disease characterized by complex inflammatory responses in the oral environment. This case-control pilot study evaluated the analytical performance of an ultra-sensitive electrochemiluminescence multiplex assay (MSD S-PLEX ® ) for salivary cyt...

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The re...

Rab4b controls hepatic glucose production during fasting through glycophagy

Abstract Hepatic glucose production, essential for maintaining glycemia, is often altered in metabolic-associated fatty liver and glycogen storage diseases. Therefore, understanding the mechanisms that regulate the glucose production by hepatocyte is pivotal. Recent studies have...

The top 10 priorities in palliative care research in France: final results of the AXEPRO study

Prioritizing research is essential to reduce waste, particularly in palliative care, a field with historically limited investment. To identify and rank the top 10 unanswered palliative care research questions in France according to patients, caregivers, healthcare professionals a...