Centre Hospitalier Universitaire de Liège

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

BACKGROUND: Mogamulizumab, an anti-CCR4 monoclonal antibody used in advanced mycosis fungoides (MF) and Sezary syndrome (SS), also depletes regulatory T cells, potentially leading to immune-related adverse events (irAEs). Unlike mogamulizumab-associated rash (MAR), other irAEs re...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

GLP-1 Receptor Agonists and Musculoskeletal Outcomes: A Systematic Literature Review and Meta-Analysis

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for the treatment of type 2 diabetes and obesity, but their effects on musculoskeletal health remain completely misunderstood. This systematic review/meta-analysis aims to synthesise clinical data on the...

Central vascular access in kidney and cancer care: devices, biomaterial strategies, and prevention of complications

Chronic kidney disease (CKD) and cancer are among the most prevalent chronic conditions that increasingly demand reliable long-term central venous access devices (CVADs), including central venous catheters (CVCs), peripherally inserted central catheters (PICCs), and implantable p...

BIOCOST: A Costing Tool for Belgian Biobanks

BACKGROUND: Biobanks are essential infrastructures for biomedical research, yet their long-term sustainability is increasingly challenged by complex and often underestimated costs. While numerous cost-accounting approaches have been proposed over the past decade, comparable empir...

Trio exome sequencing in patients with global developmental delay and intellectual disability in Rwanda

Intellectual disability (ID) and global developmental delay (GDD) are clinically and genetically heterogeneous conditions characterized by impairments in cognitive, motor, and behavioral functions. Despite advances in genomic medicine, individuals of African ancestry remain signi...

Talquetamab for people living with relapsed/ refractory multiple myeloma: plain language summary of the MonumenTAL-1 study

Plain Language SummaryWhat is this summary about?This summary describes how well talquetamab worked and its safety at a median (midpoint) of 17–26 months follow-up from the MonumenTAL-1 study, which tested talquetamab treatment for a type of cancer called relapsed/refractory mult...

Cognitive Fitness in Ageing (COFITAGE): A Multimodal and Longitudinal Neuroimaging Dataset

Purpose: Brain aging involves interrelated changes in molecular processes, neuroinflammatory mechanisms, brain macro- and microstructure, sleep physiology, and cognition. The 50 to 70 years age range represents a critical transition period, in which these subtle alterations may p...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...

Two Cases of Steroid Cell Tumour, Not Otherwise Specified, of the Ovary with Distinct Exon 3 CTNNB1 Hotspot Mutations (p.D32V and p.S45P): Further Evidence of Wnt/β-Catenin-Pathway Involvement

Background and Clinical Significance: Steroid cell tumours of the ovary, not otherwise specified (SCT-NOSs), are rare sex cord–stromal neoplasms with a poorly characterised molecular landscape, in which only exceptional CTNNB1 mutations have so far been reported and no recurrent...