Centre Hospitalier Universitaire de Clermont-Ferrand

Osteocalcin and impaired cerebral resting-state functional connectivity in postmenopausal osteoporosis: a pilot case-control study

PURPOSE: Postmenopausal osteoporosis and circulating osteocalcin have been suggested to influence brain function. Objectives aim to explore associations between brain network resting-state functional magnetic resonance imaging (fMRI) connectivity, bone status, and circulating ost...

Combining TAG ‐ 72CAR with anti‐ MUC16CAR improves the potency of ovarian cancer treatment

Ovarian cancer (OC) is typically associated with poor prognosis and high mortality. Chimeric antigen receptor (CAR) T‐cell therapy offers a promising strategy, yet its application in solid tumours remains constrained by limited efficacy and on‐target/off‐tumour toxicities. We pre...

Relapsed/refractory WAldenström macroglobulinemia patients treated by VEnetoclax with or without anti-CD20 antibody: WAVE a retrospective study of the French CLL/WM group (FILO)

Abstract Recently venetoclax (Ven) monotherapy showed promising efficacy for relapsed/refractory (R/R) Waldenström macroglobulinemia (WM), a population with significant medical unmet need. We report the efficacy and safety of Ven associated or not with anti-CD20 therapy, in a rea...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Preventing screen time in children aged 3 to 6: creation of a children's picture book

Context. Screen time for children aged 3–6 years should remain the exception, be limited in duration, and be supervised by an adult. In 2022, French children aged 3–5 years spent an average of 1 hour 22 minutes a day on screens. Activities such as reading, which are beneficial to...

Appendicular Versus Non-Appendicular Community-Acquired Intra-Abdominal Infections: A Post-Hoc Analysis of the PERICOM Multicenter Study

Background: Community-acquired intra-abdominal infections (CA-IAIs) exhibit significant clinical heterogeneity. However, most studies focusing on CA-IAIs do not stratify comparisons by infection site. Methods: This post hoc analysis of the prospective multicenter PERICOM cohort (...

Sensory plasticity of dorsal horn silent neurons as a critical mechanism for neuropathic pain

The spinal cord dorsal horn (DH) integrates sensory processing but undergoes critical plasticity following nerve injury, leading to mechanical allodynia, or “touch-evoked pain”. It has been proposed that after nerve injury, innocuous sensory neurons gain access to nociceptive-spe...

Oral health, oral follow-up and infectious risk management of rheumatoid arthritis patients on anti-TNF drugs: a survey of a French e-cohort

Abstract Background As periodontitis is a recognized risk factor for rheumatoid arthritis (RA), it should be adequately treated before the initiation of biologic disease-modifying antirheumatic drugs (bDMARDs), along with any concomitant acute oral infection. bDMARDs remains a co...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...