Centre Hospitalier Universitaire de Bordeaux

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

Subcutaneous isatuximab by on-body-injector plus bortezomib, lenalidomide, and dexamethasone in newly diagnosed transplant-ineligible multiple myeloma: ISASOCUT study

Isatuximab–bortezomib–lenalidomide–dexamethasone (Isa-VRd) has emerged as a standard of care for newly diagnosed multiple myeloma transplant-ineligible patients. A subcutaneous (SC) formulation of isatuximab delivered via an on-body injector (OBI) has been developed to facilitate...

Evaluation of Oral Health in Early Stages of Chronic Kidney Disease

Background/Objectives: Oral health may be affected by chronic kidney disease (CKD) through mechanisms including uremic toxin accumulation, immune dysregulation, and treatment-related factors, although these relationships remain poorly understood. This study aimed to describe oral...

Rapid estimation of structural brain disconnection from binary lesion masks using DeepDisco

Abstract Mapping how focal brain lesions disrupt structural connectivity is key to understanding cognition, behavior, and neurological outcomes. However, traditional diffusion tractography pipelines are computationally intensive, require specialized data and expertise, and remain...

Relapsed/refractory WAldenström macroglobulinemia patients treated by VEnetoclax with or without anti-CD20 antibody: WAVE a retrospective study of the French CLL/WM group (FILO)

Abstract Recently venetoclax (Ven) monotherapy showed promising efficacy for relapsed/refractory (R/R) Waldenström macroglobulinemia (WM), a population with significant medical unmet need. We report the efficacy and safety of Ven associated or not with anti-CD20 therapy, in a rea...

Semaglutide for Treating Paediatric Craniopharyngioma‐Related Obesity: A Multicentre Case Series

ABSTRACT Aims Obesity is a complication of childhood craniopharyngioma that remains difficult to treat. We investigated whether semaglutide was associated with a decrease in BMI among adolescents with craniopharyngioma‐related obesity. Material and Methods This multicentre retros...

Characterisation of the Novel HLA‐C*03:04:123 Allele by Sequencing‐Based Typing

ABSTRACT HLA‐C*03:04:123 differs from HLA‐C*03:04:01:02 by a single synonymous change in Exon 2.

Auditing sex/gender disparities in emergency triage with LLM-based paired comparisons

We present a domain-agnostic paired-comparison approach that uses Large Language Models (LLMs) to quantify sex/gender-related asymmetries in documented clinical decision-making. The method trains an LLM to emulate observed decisions, then evaluates sex-swapped pairs in which only...

A Reproducible MRI‐Based Pipeline for Longitudinal Tracking of Laser‐Assisted Bioprinted Cells in Three‐Dimensional Constructs

ABSTRACT Laser‐assisted bioprinting (LAB) enables precise spatial patterning of living cells within three‐dimensional constructs; however, the lack of non‐destructive, standardised methods for longitudinal evaluation remains a major limitation to construct optimisation and transl...

Use of cardiac magnetic resonance imaging after hospitalization for acute heart failure: insights from the French nationwide OFICA-2 cohort

Abstract Background Cardiac magnetic resonance (CMR) has a central role in the management of patients with acute heart failure (AHF), but timely access remains heterogeneous. We investigated real-world CMR use in patients hospitalized for AHF and its associations with demographic...

Predicting driving performance from resting-state EEG using explainable gradient boosting

Abstract Sleep deprivation substantially impairs driving performance, underscoring the need for Electroencephalography (EEG)-derived markers associated with driving-performance vulnerability under varying levels of sleepiness. In this study, resting-state EEG signals were recorde...

Timing of antifibrotic therapy and prognosis in idiopathic pulmonary fibrosis: real-world evidence from the French Colibri-ILD SNDS database

According to the French 2022 National guideline, antifibrotic therapy should be initiated as soon as a diagnosis of idiopathic pulmonary fibrosis (IPF) is made, taking into account the individual assessment of the expected benefit and risks of treatment. However, in practice, tre...

Efficacy of rTMS in Post‐Stroke Bilingual Aphasia: A Single Case Experimental Design

BACKGROUND: The application of non-invasive brain stimulation in the rehabilitation of bilingual individuals with aphasia following a stroke is understudied. Recent studies show benefits of anodal cerebellar transcranial Direct Current Stimulation in bilinguals, while in monoling...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...