Centre Hospitalier Universitaire Brugmann

Brain Tissue Proportionality and General Cognitive Ability Across Three Adult Cohorts

Abstract General cognitive ability may relate to the proportional allocation of brain tissue beyond overall tissue volume. We examined five FreeSurfer compartments using compositional data analysis: cortical gray matter, cerebral white matter, subcortical gray matter, total cereb...

Leveraging Survivor Narratives to Improve Prostate Cancer Care Engagement in Botswana: Findings From a Mixed-Methods Pilot Study

PURPOSE Prostate cancer is a leading cause of cancer-related morbidity and mortality globally, with disproportionately poor outcomes in low- and middle-income countries due to late presentation, limited awareness, and barriers to treatment. In Botswana, there is limited evidence...

Plasma p-tau217 in real-world clinical practice: distribution across clinical diagnostic categories, clinician confidence, and impact on care pathways

Plasma phosphorylated tau at threonine 217 (p-tau217) is a highly accurate blood-based biomarker for Alzheimer’s disease pathology, but evidence regarding its determinants and clinical impact in routine practice remains limited. We evaluated its distribution across real-world cli...

Fetal Postmortem Examination: Confrontation Between the Required, the Needed, and the Accepted

Highlights What's already known about this topic? What does this study add?

Should We Still Care About the Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) Transition? Evidence From a Systematic Review and Meta-Analysis

Objective Transition from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) represents a vulnerable period for transitional age youth (TAY), with high risk of disengagement and unmet needs. Evidence on effective transition models remains l...

GLP-1 Receptor Agonists and Musculoskeletal Outcomes: A Systematic Literature Review and Meta-Analysis

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for the treatment of type 2 diabetes and obesity, but their effects on musculoskeletal health remain completely misunderstood. This systematic review/meta-analysis aims to synthesise clinical data on the...

BIOCOST: A Costing Tool for Belgian Biobanks

BACKGROUND: Biobanks are essential infrastructures for biomedical research, yet their long-term sustainability is increasingly challenged by complex and often underestimated costs. While numerous cost-accounting approaches have been proposed over the past decade, comparable empir...