Centre hospitalier de l'Université Laval

Global policy determinants of national human papillomavirus vaccine introductions in 2006–2025

BACKGROUND: Although safe and effective human papillomavirus (HPV) vaccines have been available since 2006, national introduction in low- and middle-income countries (LMICs) has progressed slowly. HPV vaccine adoption may have been shaped by evolving World Health Organization (WH...

Rapid Species-Level Classification of Urinary Pathogens from Raw LC-MS/MS Signals Using Machine Learning

Abstract Urinary tract infections are among the most common infections in humans, yet their diagnosis still depends on time-consuming workflows based on microbial culture, followed by MALDI-TOF mass spectrometry. Although LC-MS/MS offers the sensitivity and specificity needed to...

From Bench to Operating Room: A Comparative Study of Tensile and Puncture Tests in Self-Assembled Constructs with Clinical Feedback

Urethral reconstruction is required for a variety of congenital and acquired conditions. Current grafting techniques rely on autologous tissues such as buccal mucosa, which are often limited by donor-site morbidity. Biomaterials could be an alternative. However, they may present...

Impact of respiratory syncytial virus immunization in older adults: the importance of a valid burden estimation

ABSTRACT Introduction In the province of Québec, Canada, a respiratory syncytial virus (RSV) immunization program restricted to seniors residing in long-term care facilities (LTCF) and those aged ≥75 years from private senior residences (PSR) was implemented in Fall 2024, with ap...

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

ABSTRACT Plasmodium falciparum parasites cause the most virulent form of malaria, a disease that remains a major global health burden. The appearance of resistance to first line artemisinin‐based therapies emphasizes the need to identify new parasite vulnerabilities to develop ne...

Microbiological and genomic approaches to study and characterize co- and cross-resistance to antimicrobial peptides in Listeria monocytogenes ATCC 19,111 variants

Abstract Background Antimicrobial peptides are considered a promising alternative to conventional antibiotics for controlling Listeria monocytogenes , a major foodborne pathogen. However, the emergence of antimicrobial resistance, including co- and cross-resistance between struct...