Centre Hospitalier Charles Perrens

Handwriting Isochrony in Autistic and Non-Autistic Children

Handwriting difficulties are frequently reported in autistic children and may interfere with academic performance. However, whether fundamental motor principles such as isochrony are preserved in autism remains largely unexplored. To address this question, fifty-five autistic and...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice

Abstract Gastrointestinal (GI) symptoms are prevalent in Autism Spectrum Disorder (ASD), yet their biological correlates remain poorly understood, notably in adults. The microbiota-derived metabolite p- cresol is reported to be elevated in the urine and stool of ASD patients, but...

Mental health and substance use in Europe: initial steps towards a common European approach

BACKGROUND AND AIMS: Comorbid substance use and other mental health disorders contribute to more than one million years lived with disability in Europe according to the Global Burden of Disease study. They require a comprehensive approach, yet, in Europe, there is considerable va...