Centre for Palaeogenetics

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study

Abstract Aims The long-term depressive symptoms trajectories across the transition to diagnosed cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational aging populations....

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Usi...

Loneliness trajectories surrounding mobility loss: The role of disability duration

Abstract Objectives Mobility limitations in later life can disrupt social engagement and increase loneliness, but trajectories may differ depending on whether limitations remain or individuals recover. This study examines loneliness trajectories around the onset of mobility limit...

α ‐Hydroxybutyrate Association With Incident Type 2 Diabetes Over 10 Years Across Different Glycemic States

ABSTRACT Aim To investigate the association between baseline plasma α‐hydroxybutyrate (α‐HB), an organic acid derived from aminoacid catabolism and glutathione anabolism, and the 10‐year incidence of Type 2 diabetes (T2DM). Materials and Methods This prospective study analysed 13...