Centre for Inflammation Research

Activity-Guided Identification of Pro-inflammatory Neutrophils with Dual Enzyme- and Metabolite-Activatable Fluorescent Probes

Abstract Neutrophils are the most abundant circulating leukocytes in the innate immune system. Primary neutrophils comprise multiple distinct subtypes that regulate antimicrobial defense and inflammatory diseases. Current fluorescent probes for imaging neutrophils cannot distingu...

Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.

BACKGROUND: Fibrosis development in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progress...

Eclipse-Related Emergency Ophthalmology Presentations Following the August 2026 Solar Eclipse in the United Kingdom

Introduction: Solar eclipses can cause solar retinopathy, but eclipse-related presentations may reflect public concern as well as true retinal injury. We evaluated the immediate ophthalmic service impact of the 12 August 2026 solar eclipse in the United Kingdom and characterised...

Microglia and border-associated macrophages play opposite roles in cerebrovascular and leukocyte responses under systemic inflammation in male mice

Microglia closely associate with the vasculature, but their roles in leukocyte trafficking and cerebral blood flow (CBF) during systemic inflammation are unclear. We show that sustained systemic inflammation leads to altered microglia-vascular interactions, leukocyte recruitment...

Promotion of long-term health in early life

Noncommunicable chronic diseases (NCDs) are on the rise in high-income countries, leading to substantial morbidity and mortality and contributing to increased resource demands and healthcare costs. Early-life exposures can initiate trajectories that culminate in NCDs later in lif...

CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune‐mediated inflammatory arthritis and ageing

Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/Endosialin is expressed by fibroblasts in the synovium, is highly upregulated during inflammation and has been proposed as a potential therapeutic target...

Acceptability of advanced Controlled Human Infection Models: The case of a pneumococcal challenge in people living with HIV and mycobacterial challenge with Bacillus Calmette Guerin in Malawi

Abstract Background Controlled Human Infection Models (CHIM) in which volunteers are experimentally exposed to pathogens are used to study pathogenesis and down select among treatment and vaccine candidates. Scientifically, CHIM studies are best conducted among at-risk population...