Centre for Immunity, Infection and Evolution

Gene-rich fungus gnat germline-restricted chromosomes are largely transcriptionally quiescent

Germline-restricted chromosomes (GRCs) constitute a unique class of chromosomes confined to germ cells. Arising in multiple evolutionarily distant lineages, GRCs have been identified in three insect families (non-biting midges, gall midges, and fungus gnats), each within the orde...

Identification of cellular double-stranded RNAs in mammalian embryonic stem cells

Abstract Antiviral defence mechanisms are typically activated upon sensing virus-derived nucleic acids. During replication, viruses generate double-stranded RNA (dsRNA) intermediates that the innate immune system can sense, triggering several defence pathways. Conversely, mammali...