Centre for Health Technology and Services Research

Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity

Glycans play fundamental roles in T cell biology; however, the glycome landscape of γδ T cells remains to be unlocked. Despite the growing importance of γδ T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment...

Orbital Apex Involvement in Sinonasal Intestinal-Type Adenocarcinoma: Impact on Distant Metastasis and Mortality

Abstract Sinonasal intestinal-type adenocarcinoma (ITAC) is often diagnosed at advanced stages. Prognosis is strongly influenced by tumor extension into critical anatomical regions contiguous with the orbit and skull base, where achieving negative margins is challenging. To ident...

Measurement properties of instruments to measure lower limb functional ability and balance after technology-assisted physical activity interventions in community-dwelling older adults: an umbrella review of systematic reviews and meta-analyses

With the growing evidence of technology-assisted interventions, psychometrically robust instruments are essential for evaluating their outcomes and providing evidence-based clinical decisions. This umbrella review aimed to determine lower-limb functional ability and balance instr...

Effects of home-based isometric handgrip or aerobic training on blood pressure variability and vascular health in older adults with elevated blood pressure and hypertension: secondary results from The HoldAge Trial

Background Hypertension is a multifactorial condition that is likely to affect older adults. We evaluated the effects of home-based isometric handgrip training (IHT) or aerobic exercise training (AET) on vascular health of older adults with elevated blood pressure (BP) and hypert...

Reliving the Moment of Departure: Post-Caregiving Adjustment After Bereavement

PURPOSE: Family caregiving often ends with the death of the care recipient, yet little is known about how former caregivers reinterpret the final phase of caregiving after bereavement. The current study explored how primary caregivers revisit their caregiving experiences during t...