Institution
Centre for Cancer Biology
Recent research
- Health & MedicineOpen access
Composite dietary and lifestyle indices capture the combined effects of multiple health-related behaviours and may better reflect real-world cancer risk and survivorship than single exposures. This umbrella review aimed to evaluate and grade the strength of evidence for associati...
- Health & MedicineOpen access
DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells
Abstract Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using com...
- Health & MedicineOpen access
ABSTRACT Background A higher ratio of IGF‐1:IGF binding protein 1 (IGFBP1) was associated with improved prognosis in the CHAARTED trial of docetaxel in participants with metastatic hormone‐sensitive prostate cancer (mHSPC). The ENZAMET trial demonstrated the survival benefit of a...
- BiologyOpen access
Prostate cancer is the most diagnosed cancer in men and remains a leading cause of cancer related mortality worldwide. A deeper understanding of the cellular and molecular mechanisms that drive prostate cancer progression is essential for improving patient management and identify...
- BiologyOpen access
ABSTRACT CEP55, a centrosomal protein frequently overexpressed in multiple cancers, is implicated in regulation of genomic instability and PI3K/AKT pathway activation, yet its role in tumor progression and the tumor microenvironment remains incompletely defined. Here, we develope...