Centre for Addiction and Mental Health

The practical impact of numerical variability on structural MRI measures of Parkinson’s disease

Abstract Numerical variability is rarely quantified in neuroimaging despite many measures relying on subtle morphometric differences across individuals. We instrumented FreeSurfer 7.3.1, a widely used neuroimaging pipeline, to simulate numerical differences across computational e...

Resilience and Protective Factors for Mental Health among Indigenous Youth in Canada: A Scoping Review

Abstract Indigenous youth’s inherent strength and resilience play a vital role in their well-being and mental health. Protective factors, closely linked to resilience, spanning individual, family, and community levels reinforce positive mental health outcomes. The purpose of the...

Evaluating the costs of developing a digital supervision tool for task-shared depression care: findings from a multi-site study in India

BACKGROUND: Task-sharing with non-specialist providers offers a promising solution to the mental health workforce shortage in low-resource settings. Supervision is essential to ensure treatment quality, but is often constrained by limited specialist availability. AIMS: This study...

Xylazine Usage and Awareness Among People Who Use Drugs in Denver, Colorado

<b>Background</b>: Xylazine, also known as “tranq,” is an alpha-2 agonist with various effects including central nervous system depression, analgesia, and vasoconstriction. Since xylazine is a non-opioid, its effects are not reversible with ,bnaloxone, complicating overdose treat...

The symbolic power of decriminalization and recriminalization in shaping stigma toward people who use drugs in British Columbia

In January 2023, British Columbia (BC) implemented a three-year decriminalization pilot to reduce harms of drug criminalization and address stigma toward people who use drugs. In May 2024, the policy was amended to “recriminalize” drug possession, a reform that excluded most publ...

Prevalence and Characteristics of Long-Stay Forensic Patients With Intellectual and Developmental Disabilities: An Ontario Population-Based Study: Prévalence et caractéristiques des patients hospitalisés pour de longs séjours dans un service médico-légal et présentant des déficiences intellectuelles et développementales : Une étude fondée sur la population de l’Ontario

Objectives This study examined the point prevalence of patients with intellectual and developmental disabilities (IDDs) in Ontario forensic inpatient units and compared the demographic, clinical, and system-level profiles of long-stay forensic patients with and without IDD. Metho...

Efficacy, Tolerability, and Safety of Pitolisant for Residual Sleepiness in Obstructive Sleep Apnea Treated with CPAP: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

There is growing evidence on the use of pitolisant for the treatment of residual excessive daytime sleepiness (EDS) in adults with obstructive sleep apnea (OSA) treated with continuous positive airway pressure (CPAP). We conducted a systematic review and meta-analysis of randomiz...