Centre de Recherches en Cancérologie de Toulouse

Hackathon on predictive modelling in systems pharmacology: design, implementation, and outcomes

Background The growing availability of multi-omics data and machine learning methods creates both an opportunity and a challenge for the systems pharmacology community: the opportunity to model drug action at unprecedented mechanistic resolution, and the challenge of equipping a...

Association between the site of emergency care and patient-centered outcomes in patients with cancer: rationale and design of the French COVER cohort

Patients living with cancer now account for a substantial and growing share of emergency department (ED) visits and carry a high burden of hospitalization and in-hospital death. Their acute presentations are frequently multifactorial - driven by disease progression, treatment tox...

PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12

Abstract Phosphoinositide 3-kinases (PI3Ks) are major regulators of cell growth, proliferation and signalling, constituting key therapeutic targets in cancer, inflammation, and other diseases. Individual class I PI3K isoforms control key cellular functions, imposing the need to g...

A cytidine deaminase biodegrader sensitises multiple cancer types to deoxycytidine analogue-based chemotherapies

Abstract Deoxycytidine (dC) analogues are widely used to treat solid tumours and blood cancers. However, their clinical efficacy is often limited by resistance mediated by cytidine deaminase (CDA), which converts these drugs into inactive metabolites. Existing CDA inhibitors have...

Beyond correlation: Intraclass correlation and bland-altman analysis reveal poor absolute agreement across multiplex cytokine immunoassay platforms

Cross-platform comparisons of serum cytokine immunoassays have often focused on rank correlation, but the extent of absolute agreement and systematic bias between platforms remains insufficiently characterized. Few independent head-to-head evaluations have compared multiple immun...

Incorporating sliding and local rigidity constraints in neural-based image registration

Image registration is widely used in various applications to estimate the deformations of moving structures in image pairs acquired at different times. Spatial regularization strategies often take a one-size-fits-all approach by imposing uniform deformation constraints across the...

A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes

Large B cell lymphomas (LBCLs) exhibit significant heterogeneity which leads to disparate treatment response, with up to 40% of patients developing refractory disease or relapsing within the first two years. To understand the cellular and molecular basis of this heterogeneity, we...

Association of plasma growth differentiation factor-15 with the frailty phenotype – Evidence from the COGFRAIL study

Background Growth differentiation factor-15 (GDF-15) has been consistently associated with physical frailty. However, it remains unclear whether GDF-15 further discriminates adverse outcomes among older adults who are already physically and cognitively impaired. Objectives To eva...

Seed-based functional connectivity of the anterior cingulate cortex and the posterior insula predicts placebo analgesia in Parkinson’s disease

Chronic pain affects up to 80% of people with Parkinson’s disease (PD) and remains difficult to treat. Functional brain connectivity can predict analgesic response in other conditions, but has not been explored in PD. To assess whether baseline resting-state functional connectivi...

Effect of the WHO ICOPE prevention program on falls and mobility functions : a retrospective study in France

Abstract Background World Health Organization developed the Integrated Care for Older People (ICOPE) prevention program in order to promote the maintenance of intrinsic capacities for older adults, based on six key domains. Each key domain is a risk factor for falls in older adul...