Centre de Recherche des Cordeliers

Targeting the Complement C1 Proteases Using Camelid-Derived Single Domain Antibodies: Production, Characterization and Possible Application for Tissue/Fluid Analysis

Background. The complement C1r and C1s proteases initiate the classical complement pathway within the C1 complex, but emerging evidence points to additional roles in tissues, including cell-intrinsic functions linked to cancer and connective tissue disorders. Few tools are availa...

Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells

Autophagy dysfunction and senescence are established drivers of aging, but their potential interaction remains poorly understood. Here we show that age-related decline of chaperone-mediated autophagy (CMA), a pathway for selective lysosomal protein degradation, changes senescent...

Wild-type and mutated ß-catenin differently repress RND3/RHOE expression in hepatocellular carcinoma

Tumor development and progression are mainly driven by oncogenic mutations but are also regulated by physical factors. Through its structural and transcriptional functions, ß-catenin is a key factor that acts on both aspects to promote liver tumorigenesis, leading to hepatocellul...

FastCNV: fast and accurate copy number variation prediction from high-definition spatial transcriptomics and scRNA-seq data

Abstract Background Predicting DNA copy number variations (CNVs) from spatial transcriptomics (ST), including Visium HD, or single-cell RNA-sequencing (scRNA-seq) data helps to distinguish malignant from non-malignant cells and to characterize the clonal architecture of tumor cel...

Quantification of absolute IgG concentration in bat sera

Abstract Bats are endowed with a remarkable capacity to withstand important pathogens through evolutionary adaptations in their immune systems. Antibodies are essential component of the adaptive immune response and serve as a crucial biomarker, indicating both present and past pa...

Cuproptosis: an emerging member of the immunogenic cell death family

Cell death was long considered the terminal consequence of cellular stress or damage, and distinct cell death modalities were classified according to their molecular execution mechanisms rather than their immunological impact [ 1 , 2 ]. This reductionist view has progressively be...