Central Institute of Mental Health

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...

Procalcitonin as a predictor of length of stay in patients with odontogenic infections

OBJECTIVES: Our study aimed to evaluate procalcitonin (PCT) as a prognostic marker in advanced odontogenic infections. In addition, we sought to identify further prognostic markers that could be used to predict the length of hospital stay (LOS). MATERIALS AND METHODS: We retrospe...

Mental Health Disorders, Suicide Attempts, Substance Use, and Substance Use Disorders in Adults with Fetal Alcohol Spectrum Disorders: A Gender-Separated Study

Abstract Fetal alcohol spectrum disorders (FASD) are a group of neurodevelopmental disorders caused by alcohol exposure during pregnancy. FASD is associated with various neurocognitive disorders over the entire lifespan. Comorbid mental health disorders seem to be highly prevalen...