Central Hospital of Zibo

Targeting an IL-17/IL-36 pathogenic hub in hidradenitis suppurativa with a bispecific antibody

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with a high unmet need, particularly for treatment-resistant tunnels. Integrated multiomics analysis revealed that HS tunnels are spatially organized, self-amplifying inflammatory circuits driven by synergistic...

Chaperone-mediated autophagy as a context-resolved proteostatic decision node in breast cancer

Therapy resistance, metastatic relapse, and immune evasion are major contributors to breast cancer–related mortality; however, the proteostatic systems that support phenotypic plasticity remain incompletely understood. Chaperone-mediated autophagy (CMA) is a selective lysosomal p...

Static and dynamic biomechanical responses of the lumbar spine under different loads: A finite element study

Lumbar spinal loads differ across various scenarios, including lumbar extension in the lateral recumbent position, seated/standing trunk extension, upright sitting or standing, muscular tension, muscular relaxation, and whole-body vibration. Nevertheless, systematic comparative s...

Prevalence and geographic variation of enteric pathogens among asymptomatic individuals in China: a nationwide, cross-sectional, multiplex molecular survey

The increasing use of multiplex molecular assays has improved the detection of enteric pathogens, but baseline carriage in asymptomatic populations remains poorly characterized, complicating the interpretation of positive test results. We aimed to investigate the prevalence and g...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Eupatilin Alleviates Acute Myocardial Ischemia‐Reperfusion Injury in Rats via the Akt/GSK‐3β Pathway by Targeting COXs

ABSTRACT Eupatilin confers cardioprotection against myocardial ischemia‐reperfusion injury (MIRI). Cyclooxygenases (COXs) serve as key rate‐limiting enzymes for prostaglandin biosynthesis. This study investigated the effects of eupatilin on COXs. H9c2 cells subjected to oxygen‐gl...

Profiles of AI literacy and educational needs of nursing students: a mixed‑method study

Artificial intelligence (AI) is increasingly being integrated into healthcare. This integration provides new opportunities for nursing but also creates challenges. AI literacy is now regarded as an essential competency for nursing students. However, its levels are heterogeneous,...

Balloon-assisted radial release for retrieval of a surgically suture-fixed inferior vena cava filter: a case report

The retrieval of an inferior vena cava (IVC) filter is essential for preventing complications related to the filter. Surgically induced suture fixation is an extremely rare cause of filter entrapment and presents unique technical challenges. This case describes a balloon-assisted...

Ex Situ Luring Sterilization and Visual Tracking for Wound Healing Acceleration

Abstract Conventional sterilization methods, such as advanced oxidation and cationic antimicrobial action, inevitably cause harm to host tissues because of their in situ attack mode. The residual bacterial debris further increases the risk of secondary infection. Additionally, th...

Glyoxal induces arterial injury through the inactivation of receptors and signaling pathways

Glyoxal exposure is associated with a spectrum of adverse health outcomes, including arterial injury. While existing evidence confirms that glyoxal targets oxidative stress and the mitogen-activated protein kinase pathway, the precise underlying mechanism of glyoxal-induced arter...

LncRNA DLGAP1-AS2 promotes ESCC progression and indicates unfavorable prognosis via the miR-101-3p/EZH2 axis

LncRNAs are crucial regulators and biomarkers in various cancers. However, their expression and functions in esophageal squamous cell carcinoma (ESCC) remain largely unexplored. This study explored the clinial relevance and mechanisms of LncRNA DLGAP1-AS2 in ESCC. Utilizing the G...

Association between thymidine kinase 1 and clinicopathological high-risk features in breast cancer

Thymidine kinase 1 (TK1) is a cell-cycle-regulated enzyme involved in DNA synthesis and is closely linked to tumor cell proliferation. This study investigated whether serum TK1 concentration is associated with clinicopathological high-risk features in breast cancer (BC) and wheth...

Integrative Transcriptomic Analysis Identifies Glycolysis/Ferroptosis-Associated Candidate Genes in Gastric Cancer

Background: The crosstalk between glycolysis, ferroptosis and the gastric cancer (GC) immune microenvironment remains poorly defined. This study aims to uncover glycolysis/ferroptosis-related regulators of the GC immune microenvironment.Methods: Transcriptomic datasets from The C...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Bilateral ascending dry gangrene following documented smear-positive malaria in a patient with multivalvular rheumatic heart disease and normal CT angiography findings: a case report

Introduction: Symmetrical peripheral gangrene (SPG) is a rare syndrome characterized by distal ischemic necrosis affecting two or more extremities in the absence of major arterial occlusion or vasculitis. Malaria is an uncommon but recognized trigger, most often described in asso...