Central Hospital of Wuhan

Combined Bioinformatic Analysis and RNA Sequencing Uncover Key Tinnitus-Related Molecules in the Cingulate Gyrus

Tinnitus arises from maladaptive plasticity and abnormal synaptic function, not only in auditory pathways but also in limbic regions. Among these, the cingulate gyrus plays a pivotal part in shaping the emotional burden and sensory filtering disturbances often seen in tinnitus pa...

Gut microbiome mediates the protective effects of empagliflozin on experimental abdominal aortic aneurysm formation and progression

Abdominal aortic aneurysm is a life-threatening vascular disease lacking effective pharmacotherapies. This study aimed to investigate the protective effect of empagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor, against angiotensin II (AngII)-induced AAA in ApoE −/...

A bladder microenvironment-adaptive ceria nanozyme hydrogel enables urea-responsive intravesical chemo-immunotherapy

Bladder cancer intravesical therapy remains limited by rapid urinary washout, insufficient penetration across the bladder mucosal barrier, and an immunosuppressive tumor microenvironment. Here, we developed a bladder microenvironment-adaptive chemo-immunotherapy system, Gel/UCeNZ...

Longitudinal Study on Post‐Traumatic Stress Disorder, Anxiety, and Depression Among Medical Staff in China

ABSTRACT Background Evidence of the longitudinal relationship between anxiety, depression, and post‐traumatic stress disorder (PTSD) is not uniform. This study aimed to explore the dynamic changes, independent factors, and bidirectional predictive relationships of anxiety, depres...

Anterior intervertebral osteotomy and fusion (AIOF): an IPUP-guided standardized extension of anterior cervical discectomy and fusion for multilevel cervical spondylotic myelopathy

Abstract Purpose To evaluate the clinical and radiographic outcomes of anterior intervertebral osteotomy and fusion (AIOF), guided by the inflection point of the uncinate process (IPUP), for the treatment of multilevel cervical spondylotic myelopathy (MCSM), and to compare these...

Factors influencing delayed onset of lactation: a systematic review and meta-analysis

Delayed onset of lactogenesis (DOL), defined as the absence of breast fullness or milk coming in beyond 72 h postpartum, may impair breastfeeding success. Reliable estimates of its incidence and associated factors are needed to guide clinical support. Following PRISMA 2020, we sy...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Impact of smoke-free legislation on cigarette price and affordability in Wuhan, China: a repeated cross-sectional study

The smoke-free legislation (SFL) in Wuhan, China was adopted in January 2020. While its health benefits are documented, the impact on cigarette prices and affordability among smokers remains unclear. This study assessed the impact of Wuhan’s SFL on cigarette prices and affordabil...