Central Hospital of Putuo District

Risk factors for arthroscopic surgical outcomes in patients with rotator cuff tears based on LASSO regression analysis and construction of a predictive model

Rotator cuff tear outcomes after arthroscopic repair vary considerably. Reliable individualized risk prediction tools remain limited. This study identified independent risk factors for poor outcomes after arthroscopic rotator cuff repair and developed a predictive nomogram. This...

Antibiotic-loaded PMMA bone cement promotes diabetic wound healing via induced membrane formation: a transcriptomic and mechanistic study

Abstract DFU is a prevalent complication among diabetic patients, significantly impairing their quality of life.PMMA-induced membrane therapy has gained increasing attention as a specialized healing tissue closely linked to bone regeneration. This study aims to explore the impact...

Integrated analysis of single-cell and transcriptome data reveals temporal dynamics of microglial phagocytic reprogramming in neuropathic pain progression

Abstract Neuropathic pain (NP) often progresses from acute to chronic, but the mechanisms driving this transition remain unclear. Microglia play a central role in spinal sensitization, yet their functional evolution during pain chronification is poorly understood. Through integra...

Sequential method for determining the effective dose of remimazolam combined with sufentanil for cervical dilation in hysteroscopic surgery

This study investigated the 50% and 95% effective doses (ED50 and ED95) of remimazolam combined with sufentanil for cervical dilation during hysteroscopic surgery. Prospective single-center dose-finding study using a modified Dixon up-and-down sequential method. Twenty-five patie...

Dental caries among 12-year-old adolescents in shanghai: a cross-sectional study on prevalence, severity, and associated risk factors

This study aimed to assess the prevalence, severity, and associated factors of dental caries in permanent teeth among 12-year-old adolescents in Shanghai, China. A cross-sectional study was conducted in 2021 among 1,305 adolescents from six randomly selected districts. Clinical e...

Colorectal cancer-derived IGFBP2 promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation

Colorectal cancer (CRC) liver metastasis (LM) is a leading cause of cancer-related death, with pre-metastatic niche (PMN) formation being critical for metastasis. Insulin-like growth factor binding protein 2 (IGFBP2) is overexpressed in metastatic CRC, but its role in intrahepati...

Association between the time window of rash recurrence and the risk of renal involvement within 6 months in children with immunoglobulin A vasculitis

Renal involvement is a major determinant of long-term outcome in childhood immunoglobulin A vasculitis (IgAV). We examined whether the timing of the initial rash recurrence was associated with renal involvement within 180 days, while accounting for temporal ordering, rash phenoty...