Central European Institute of Technology

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Mastodon: the command center for large-scale lineage-tracing microscopy datasets

Understanding development in living organisms requires following the divisions, movements, and fates of cells. While advances in microscopy have enabled whole-embryo imaging at the cellular level, extracting and analyzing cell lineages from these massive datasets remains a signif...

Atlas of cell types and regulatory elements underlying human facial diversity

Abstract Human genetic diversity generates an astonishing variety of facial shapes, and craniofacial anomalies rank among the most common birth defects. Identifying the cellular mechanisms that mediate the genome’s influence on facial variation remains a challenge. Here we create...

Consensus-Based Definitions for Vocal Biomarkers: The International VOCAL Initiative.

Introduction: Voice-based health technologies are growing rapidly, but they lack standardized terminology, which hinders interdisciplinary collaboration, research quality, and clinical translation. The objective of this work was to develop universally accepted definitions in the...

Analysis of structural errors in the AlphaFold DB v4 and v6

3D protein structures predicted using machine-learning techniques have become routinely used in research. One of the major sources of the predicted structures is the AlphaFold DB, providing predictions for over 240 million proteins. For a proper interpretation of predicted protei...

Past and present phage therapy research and practice in the Czech Republic – contribution to phage therapy in Europe

Renewed interest in bacteriophage therapy, driven by the global rise of antimicrobial resistance, is accelerating efforts to establish its rational, evidence-based use in clinical practice. This review provides a comprehensive overview of the historical milestones, current status...

Oxygen-Pressure-LimitedRecovery of the Hematite α-Fe2O3(0001) Surface from a Reduced Fe3O4(111)-likeLayer

Abstract The oxidation kinetics of hematite α-Fe2O3(0001) surfaces are vital for its applications in catalysis, environmental remediation, and industrial processes. Despite prior studies, the roles of temperature, oxygen partial pressure, and oxygen chemical potential in controll...