Central Drug Research Institute

Dopamine alters macrophage metabolism promoting intracellular Mycobacterium tuberculosis survival

Dopamine (DA) is thought to aggravate progress of bacterial infections and enhance risk of intracellular bacterial infection like tuberculosis (TB). Though TB patients are known to present with high dopamine levels the causal link between them has remained unexplored. Mycobacteri...

Uracil-Thianthrenium Salts (Uracil-TT+BF4–) as a Coupling Partner in Sonogashira Cross-Coupling Reactions: Access to 5-Alkynyl Uracils and Synthetic Applications

Abstract Cross-coupling reactions are powerful tools for forging two different organic fragments via formation of C–C or C–heteroatom bonds. Herein, we for the first time synthesize a bench-stable cross-coupling reagent, uracil-TT+BF4–, for Sonogashira-type reaction to install an...

TKL3 regulates blood-stage fitness, male gamete fertility, and transmission-stage development in Plasmodium berghei

Malaria parasites must undergo complex developmental transitions to complete their life cycle and transmit between vertebrate and mosquito hosts. These transitions are tightly regulated by protein phosphorylation events, yet the specific kinases involved remain poorly characteriz...

A Small Molecule Substrate Mimic to Inhibit Bacterial Hsp70 Chaperone Function

Given the rapid spread of antibiotic resistance worldwide, it is imperative to develop new strategies against pathogenic bacteria. Here, we report a small‐molecule inhibitor of bacterial heat shock protein 70 (Hsp70), called DnaK, a central component of the bacterial protein chap...

miR-451a is a differentially expressed blood-based microRNA in newly diagnosed CML identified by high-throughput profiling

Abstract Background microRNAs (miRNAs) are emerging as promising biomarkers in hematological malignancies due to their stability in blood. This study aimed to investigate the differential expression of miRNAs in chronic myeloid leukemia (CML) and evaluate the potential of miR-451...