Central Clinical Hospital

Beyond Histocompatibility: Donor Tissue Immune States and Their Role in Heart Transplantation

Heart transplantation transfers not only donor alloantigens and functional myocardium but also a pre-existing tissue environment shaped by resident immune, vascular, stromal, and parenchymal populations. This review examines the hypothesis that the biological state of donor tissu...

Innovative application of pressure gradient measurement in internal carotid stenosis in patients undergoing carotid artery stenting (NOTICE-CAS): study protocol for a randomized, assessor-blinded, parallel-group clinical trial

Atherosclerotic stenosis of the internal carotid artery (ICA-S) is among the significant causes of ischemic stroke. Current noninvasive imaging techniques often lack the precision to accurately determine hemodynamic significance. Although carotid artery stenting (CAS) is benefici...

RED-S IN ENDURANCE ATHLETES — SKELETAL CONSEQUENCES OF CHRONIC LOW ENERGY AVAILABILITY

Background. Relative Energy Deficiency in Sport (RED-S) is an increasingly recognized health problem among endurance athletes. The main mechanism leading to the development of RED-S is low energy availability (LEA), resulting from insufficient energy intake in relation to exercis...

Beyond electrical stimulation: toward neurotransmitter-mediated synaptic prostheses

Abstract Synaptic dysfunction and neurotransmitter imbalances are central to the pathogenesis of numerous neurological disorders. Conventional systemic pharmacological treatments often lack spatiotemporal precision, while traditional electrical stimulation is fundamentally limite...

Exploring birth options after three or four cesarean sections in Poland: maternal and neonatal outcomes following vaginal vs repeat surgical deliveries

OBJECTIVES: Postpartum depression (PPD) profoundly affects maternal health and disrupts mother-infant bonding, with lasting effects on infant development. The causal roles of hormones that change most dramatically during the perinatal period, including estradiol, cortisol, and pr...

Reflectance confocal microscopy and pathological correlation of tumor microenvironment in adnexal cancers during balstilimab treatment

Adnexal carcinomas (AC) are rare, locally aggressive tumors with limited systemic treatment evidence and no validated immunotherapy biomarkers. Reflectance confocal microscopy (RCM) enables non-invasive, in vivo tumor microenvironment (TME) imaging at near-histologic resolution....