Central China Normal University

Finite Element Error Analysis for Elliptic Parameter Identification with Power-Type Nonlinearity

Abstract. This paper studies the numerical analysis of a parameter identification problem governed by elliptic equations with power-type nonlinearity. We propose a numerical reconstruction via a suitable least-squares minimization problem based on piecewise linear finite elements...

Conditional diffusion for single-cell Hi-C data imputation and enhancement with scHiC-Diff

Single-cell high-throughput chromosome conformation capture (scHi-C) enables the analysis of cell-to-cell variability in three-dimensional (3D) genome organization, but its utility is severely limited by pervasive technical dropouts, leading to extremely sparse contact maps. Accu...

Impaired Neural Pattern Separation During Implicit Emotion Regulation in PTSD: An MVPA fMRI Study

Abstract Implicit emotion regulation (IER) operates automatically and supports adaptive social–affective functioning. Although PTSD involves marked IER disturbances, the large-scale functional connectivity architecture supporting implicit emotional processing remains unclear. The...

The effect of social robot authority on epistemic vigilance in early childhood

Social robots are increasingly deployed as tutors and learning partners, yet their authority cues may discourage children from questioning or verifying information. We investigated whether robot authority influences Chinese children’s epistemic vigilance and which source of autho...

A trans-therapeutic signature of recovery in internet gaming disorder: From shared network reorganization to molecular underpinnings.

Background and aims: A variety of self-regulation interventions have shown efficacy in treating Internet Gaming Disorder (IGD), but their shared and unique neurobiological mechanisms remain unclear. This study aims to identify a common, trans-therapeutic neural signature of recov...

Marital satisfaction and parent-reported emotional competence in Chinese preschoolers: serial indirect associations through mindful parenting and parental involvement

Guided by Belsky’s parenting process model, this pooled cross-sectional study examined a theory-ordered pattern of statistical associations linking marital satisfaction, mindful parenting, parental involvement, and parent-reported emotional competence. Participants were 5,303 mar...

From role to competency: mapping competencies for data visualization services among academic librarians

Purpose This study aims to develop a role-oriented competency framework for data visualization services (DVS) among academic librarians. It seeks to address the limitations of existing competency models, which are often static and insufficiently aligned with librarians’ actual se...

Metal- and Photosensitizer-Free Radical Strategy for the Construction of Fluorinated Oxiranes

Abstract Fluorinated oxiranes are valuable structural motifs in medicinal chemistry and materials science, yet their synthesis remains challenging due to the limited availability of efficient and general methods. Herein, we disclose a photoinduced radical epoxidation strategy tha...

RAFA: RNA all-atom structure reconstruction from sparse anchor coordinates

SUMMARY: We present RAFA, a C ++ command-line tool for RNA all-atom structure reconstruction from sparse or partial coordinates. RAFA targets settings in which coarse-grained modelling, low-resolution fitting, or partial experimental interpretation provides RNA anchor atoms but n...

More than a loading bar: Conversational silence and anthropomorphic latency cues in mental health chatbots

Mental health chatbots increasingly rely on conversational interaction to support users' emotional well-being, yet little is known about how users interpret temporary silence while waiting for system responses. Existing research on social presence and anthropomorphic interaction...

Exploring ASD Identification Using Different Types of Eye-Tracking Features

Eye tracking offers a non-invasive way of examining social visual attention in children and may support the objective identification of autism spectrum disorder (ASD). However, small-sample studies are often affected by individual differences, inconsistent feature selection, and...

Measuring the novelty of biomedical papers using the latent distances between knowledge units

Measuring the novelty of scientific papers is a central concern in research evaluation and scientometrics. From a recombination perspective, prior studies have largely focused on the co-occurrence of knowledge units to assess the novelty of scientific papers. However, these studi...

Optimal estimators and tests for reciprocal effects

The $p_1$ model plays a fundamental role in modeling directed networks, where the reciprocal effect parameter $ρ$ is of special interest in practice. However, due to nonlinear factors in this model, how to estimate $ρ$ efficiently is a long-standing open problem. We tackle the pr...

Drawing as an encoding strategy for memory: An fNIRS study

Drawing reliably improves memory relative to other encoding strategies (such as reading and writing), a phenomenon known as the drawing effect. Although behavioral studies have documented this advantage, the neural mechanisms supporting it remain unclear. The present study examin...

Physics informed machine learning predicts binding free energy changes in protein-RNA complexes upon mutations

Protein-RNA interactions are central to gene regulation, yet predicting mutation-induced changes in binding free energy (ΔΔG) remains difficult due to sparse, heterogeneous measurements and strong imbalance in mutation types. Here we present Pred-MutPRI, a physics-informed machin...

Evaluating Large‐Language Models in Bioinformatics Applications

ABSTRACT Large language models (LLMs) have significantly revolutionized natural language processing through their strong capabilities in text generation and reasoning. Yet, their applicability to bioinformatics applications remains largely unexplored. Here, we systematically eval...

Spectral radius and Hamiltonicity in generalized split graphs

A graph G ˆ is a split graph if its vertex set can be partitioned into a clique S and an independent set I , and the cross edges join a vertex in S to a vertex in I . A generalized split graph G is obtained from the split graph G ˆ by replacing each vertex v of I with a clique S...

A Selective ERα Photodegrader for Precise and Efficient Breast Cancer Treatment

Abstract Breast cancer is the most prevalent malignancy in women, with over 70% of cases being estrogen receptor α (ERα)-positive. Photodynamic therapy (PDT) is spatially precise yet limited by tumor-selective photosensitizers. Herein, we report the first co-crystal structure of...

User engagement behaviours with identity-disclosed social bots on social media: the role of perceived human–machine differences

Purpose This study examines how users interpret identity-disclosed social bots on social media, how perceived human–machine differences shape psychological response orientations and how these orientations are enacted through visible engagement behaviours. Design/methodology/appro...

Photoinduced Disruption of Bisazo Photoswitch-Functionalized Amphiphilic Nanovesicles for High-Efficiency Nanofungicide Delivery

Abstract Photoresponsive nanocarriers are one of the intelligent delivery systems for achieving ordered and controlled drug release. In this study, we developed a fluorescent molecular switch by attaching azo groups to both ends of a nonaethylene glycol (PEG-9) chain. This switch...