Centers for Disease Control and Prevention

Advanced molecular poliovirus diagnostics across multiple real-time PCR platforms with locked nucleic acids and primer overhangs

This study details the development and validation of five real-time RT-PCR assays for the intratypic differentiation (ITD) of polioviruses and the discrimination of vaccine-derived polioviruses (VDPVs) utilizing locked nucleic acid (LNA) technology and primer overhangs. Updated a...

Validation of a National Pediatric HIV Risk Screening Tool at 31 Health Facilities in Zambia

BACKGROUND: To improve testing efficiency, Zambia introduced a national pediatric human immunodeficiency virus (HIV) Risk Screening Tool (HRST) in 2019. However, concerns about its sensitivity led to its suspension in 2021 pending formal evaluation. We therefore undertook a forma...

A Multistate Investigation of Serious Adverse Events, including Deaths, following Ceftriaxone Injections, September 2024–August 2025

BACKGROUND: Reports of ceftriaxone serious adverse events (SAEs), including deaths, from multiple jurisdictions during December 2024-January 2025 prompted a nationwide investigation to evaluate product safety, characterize SAEs, and assess for changes in baseline adverse event oc...

Chronic Disease-Related Social and Behavioral Risk Factors and Conditions Among Non-Hispanic American Indian and Alaska Native People: Behavioral Risk Factor Surveillance System, 2011-2023.

The findings from this study can be used to inform multilevel interventions in non-Hispanic AI/AN communities. Interventions might consider including strategies that address individual risk factors and health-related social needs.

Economic insecurity, technology, and violence: how socioeconomic status moderates support for political violence

This study examines how fear of economic insecurity and technology-related fear shape support for political violence in the U.S., with particular attention to the moderating role of socioeconomic status (SES). Drawing on nationally representative data from the 2024 Chapman Univer...

Determinants of scaled implementation for electronic laboratory information systems in 27 clinical laboratories in Côte d’Ivoire: a mixed-methods study applying the Consolidated Framework for Implementation Research (CFIR)

Abstract Background Electronic laboratory information systems (LIS) are critical for promoting data quality and improving laboratory performance, but sustained implementation following system deployment in resource-limited settings can be challenging. The OpenELIS project in Côte...

An ecological time-series study of heat-related illness in Honolulu County, Hawaiʻi: implications for heat preparedness and public health response

Heat-related illness (HRI) is a growing public health concern. HRI risk in Hawaiʻi has not previously been reviewed to determine the risks of heat on public health and well-being. This study summarizes HRI in Honolulu County and evaluates the relationship between local daily heat...