Center for Translational Molecular Medicine

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Living donor valves for valve replacement in pediatric patients, come with the risk of immune rejection of the implanted tissue. To address this, and increase the options for living implants in pediatric patients, we previously developed a lentiviral immune-shielding strategy tha...

Specificity, frequency, and phenotype of citrullinated-specific T cells vary with disease activity in rheumatoid arthritis

In rheumatoid arthritis (RA), CD4 + T cells specific for citrullinated antigens (cit-antigens) are key drivers of disease, but knowledge about epitopes and phenotypes remains limited. We characterized the frequency and phenotype of cit-specific CD4 + T cells in peripheral blood u...

Harnessing macrophage signaling pathways and scalable engineering for next-generation immunotherapies

Macrophages have emerged as promising candidates for cell-based immunotherapies due to their intrinsic plasticity, tissue-infiltrating capabilities, and central roles in orchestrating immune responses. Their phenotypic and functional diversity within tissues and the tumor microen...

Real-world safety and effectiveness of olaparib maintenance after first-relapse platinum-sensitive ovarian cancer in Japan: a multicenter historical cohort (JGOG3026)

OBJECTIVE: The primary objective of the study was to evaluate the safety and effectiveness of olaparib maintenance therapy in Japanese patients with platinum-sensitive first-relapsed ovarian cancer. The secondary objective was to survey the treatment given after the olaparib main...