Center for Pediatric Endocrinology Zurich

Hypobaric hypoxia at 3,466 m suppresses hepatic bile acid metabolism and remodels the tumor lipidome in mice

Abstract Background Systemic hypoxia induces whole-body metabolic adaptation, but its impact on tumor metabolism and hepatic bile acid (BA) pathways remains poorly defined. Methods We investigated how high-altitude (HA) hypobaric hypoxia at 3,466 m affects tumor growth, tumor lip...

Performance of point‐of‐care tests for diagnosing feline immunodeficiency virus infection in captive African lions ( Panthera leo )

Point-of-care (PoC) antibody (Ab) testing forms an integral component of feline immunodeficiency virus (FIV) diagnosis in both domestic and non-domestic felids, with test kits designed for use in domestic cats frequently extrapolated for use in their wild counterparts. The SNAP®...

A retrospective analysis of bacterial pathogens in wounds in an equine hospital (2017–2022)

Summary Background Bacterial infections are a major cause of morbidity in horses, particularly in soft tissue wounds (STW) and surgical site infections (SSI). Rising antimicrobial resistance poses challenges for timely treatment. Knowledge of common pathogens and their resistance...

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcom...