Center for Health, Exercise and Sport Sciences

Association of FOXP3 Gene Polymorphisms with Skin, Vulvar and Ectocervical Squamous Cell Tumors

Background and Objectives: Squamous cell tumors arise from squamous epithelial cells. Polymorphisms in the FOXP3 gene may influence malignancy susceptibility. This study evaluated the potential association of FOXP3 rs3761548 (−3279 A/C) and rs2280883 (IVS9+459 T/C) polymorphisms...

Williams–Campbell syndrome in an adult previously treated as allergic bronchopulmonary aspergillosis: a diagnostic challenge

Abstract Introduction Williams-Campbell Syndrome (WCS) is a rare congenital syndrome of unknown origin, characterized by defective or completely absent bronchial wall cartilage which can lead to distal airway collapse, forming bronchiectasis distal to the collapsed bronchi. The e...

Interaction of walking activity and long-term air pollution on exacerbation rate in COPD

Background Regular walking activity can improve the prognosis in people with chronic obstructive pulmonary disease (COPD). However, its benefit may be reduced when living in highly polluted areas. Aim To assess the combined effects of walking activity and air pollution on the rat...

Hip and groin pain in physically active adults with a focus on terminology, clinical examination and imaging: A formal ESSKA‐EHPA‐ESMA Consensus

Abstract Purpose This European Society of Sports Traumatology, Knee Surgery and Arthroscopy–European Hip Preservation Associates–European Sports Medicine Association (ESSKA‐EHPA‐ESMA) formal consensus aims to provide evidence‐ and expert opinion‐based recommendations for the term...

Maximal O2 Uptake Is Higher During Whole-Body Compared to Lower-Body Exercise due to Higher Convective, but not Diffusive, O2 Transport

PURPOSE: Maximal O2 uptake (V̇O2max) is higher during whole-body compared to lower-body large muscle mass exercise. However, whether this is explained by differences in convective or diffusive O2 transport is unclear. We examined differences in components of the O2 pathway and mu...

Integrated Bioinformatic and Experimental Analysis of SLFN11 Expression and Clinical Significance in Locally Advanced Rectal Cancer

Background/Objectives: Schlafen 11 (SLFN11) encodes a DNA damage response protein implicated in sensitivity to DNA-damaging therapies and has been proposed as a predictive biomarker in several malignancies. This study aimed to characterize SLFN11 expression and evaluate its progn...

Association between body composition and perimenopausal symptom severity in Irish women

Background Perimenopause is associated with somatic, psychological, and urogenital symptoms that may negatively impact quality of life. Changes in body composition, including increased body fat and central adiposity, are common during midlife. While elevated body mass index (BMI)...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...

Perioperative tranexamic acid and postoperative haematuria after transvesical prostatectomy: a prospective observational cohort study

Bleeding and postoperative haematuria remain clinically relevant after open simple prostatectomy. Tranexamic acid (TXA) may reduce bleeding through antifibrinolytic activity, but evidence in open prostate surgery for benign prostatic obstruction is limited. This study evaluated p...