Center for Health, Exercise and Sport Sciences

Association between body composition and perimenopausal symptom severity in Irish women

Background Perimenopause is associated with somatic, psychological, and urogenital symptoms that may negatively impact quality of life. Changes in body composition, including increased body fat and central adiposity, are common during midlife. While elevated body mass index (BMI)...

Integrated Bioinformatic and Experimental Analysis of SLFN11 Expression and Clinical Significance in Locally Advanced Rectal Cancer

Background/Objectives: Schlafen 11 (SLFN11) encodes a DNA damage response protein implicated in sensitivity to DNA-damaging therapies and has been proposed as a predictive biomarker in several malignancies. This study aimed to characterize SLFN11 expression and evaluate its progn...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...

Perioperative tranexamic acid and postoperative haematuria after transvesical prostatectomy: a prospective observational cohort study

Bleeding and postoperative haematuria remain clinically relevant after open simple prostatectomy. Tranexamic acid (TXA) may reduce bleeding through antifibrinolytic activity, but evidence in open prostate surgery for benign prostatic obstruction is limited. This study evaluated p...