Center for Discovery

Accuracy of commercial pollen forecasts in the United States

Approximately 80 million Americans suffer from seasonal pollen allergies, and many rely on commercial pollen forecasts to guide exposure reduction and medication timing. However, these forecasts are proprietary, and their accuracy has never been comprehensively evaluated. Here, w...

Applying Lifestyle Medicine to Improve Health Outcomes in People With Intellectual and Developmental Disabilities

Individuals with intellectual and developmental disabilities (I/DD) and autism spectrum disorder experience disproportionately high rates of chronic disease, often exacerbated by systemic care barriers. Despite these concerns, interventions for this population rarely target overa...

Purine and pyrimidine analogs differentially regulate cell wall precursor biosynthesis to control β-lactam susceptibility in methicillin-resistant Staphylococcus aureus

(MRSA). We previously showed that the pyrimidine analogs 5-fluorouracil (5-FU) and 5-fluorouridine (5-FUrd) synergize with β-lactams. Here, we extended this by evaluating additional nucleotide metabolism-targeting agents. Gemcitabine (Gem) and mitomycin C (Mito), such as 5-FU and...

Functional connectivity of the locus coeruleus in anxiety and posttraumatic stress disorder reveals convergent mapping to the cingulate cortex and insula using ultra-high field 7 Tesla MRI

Abstract Cortical and subcortical correlates of anxiety and stress disorders have been well defined over recent decades. However, the role of the locus coeruleus (LC), which is responsible for synthesizing and releasing a majority of the brains’ norepinephrine, has been less wide...

Prenatal Water Fluoride Exposure and Children’s Behavioral Problems

Importance Although fluoride exposure at high levels during the perinatal period has been associated with socioemotional problems among children, there is limited evidence regarding potential associations at lower levels of fluoride exposure, particularly in the US. Objective To...

Has the Pendulum Swung Too Far? Ethical Issues in the Conservative Use of Prescription Opioids

Abstract The opioid crisis is an undeniable public health emergency that has impacted far too many for far too long. The irresponsible prescription and use of opioids has caused, and continues to create, harm to a large number of people; yet what irresponsible means in this situa...

Multidisciplinary Approaches to the Management of Spinal Care: A Narrative Review

Abstract For patients with spinal care conditions including degenerative disease, deformity, traumatic injury, and complex pain syndromes, care is frequently fragmented across multiple specialists. This process can delay diagnosis, create complexity in communication, and result i...

Altered hippocampal lipid profile underlies anxiety-like behavior secondary to mild traumatic brain injury

Abstract Traumatic brain injury (TBI) remains a major cause of neurological morbidity worldwide, and mild TBI (mTBI) is frequently associated with emotional disturbances, including anxiety-like behavior. Although classical mechanisms of secondary injury have been extensively char...

Implementation of clinical grading committees in internal medicine sub-internships: implications for assessment accuracy and standardization

The Internal Medicine clerkship has faced challenges in ensuring fair and accurate grades, with past studies examining areas including unconscious bias, inter-rater reliability, and variability. To address these issues, the Alliance for Academic Internal Medicine recommends the u...

How Equity and Quality Are Considered by Cancer Centers Offering Practice-Integrated Telehealth Visits: A Qualitative Study

INTRODUCTION: The COVID-19 pandemic forever changed health care delivery and led to a rapid uptake in telehealth visits. However, the quality and equity of these visits compared to in-person visits are unknown. This analysis interviewed oncology practitioners to understand how US...