Center for Clinical Research Dalarna

A first-in-human, phase I/IIa trial of the T cell immunotherapy personalised tumour trained lymphocytes in patients with advanced colorectal cancer: Study protocol

Background Adoptive T cell therapy is a promising alternative to conventional therapies for certain solid tumours. Personalized tumour-trained lymphocytes (pTTL) is an autologous T cell therapy derived from tumour-draining regional lymph nodes (RLNs), trained to target patient-sp...

Bone morphogenetic protein 10 and one-year outcomes after open revascularisation in symptomatic peripheral arterial disease or carotid stenosis

Abstract Background Bone morphogenetic protein 10 (BMP10) has atrial-specific and vascular properties and may reflect both atrial and vascular pathophysiology. We investigated whether BMP10 levels were associated with new-onset atrial fibrillation (AF), major adverse cardiovascul...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

Thematic alignment across expert-guided and machine-derived topic models in Positive Energy District characterization

Positive Energy Districts (PEDs) are increasingly framed through both expert-driven policy narratives and data-driven analyses of emerging project discourse. However, the extent to which different knowledge extraction approaches produce conceptually meaningful representations of...

Techno-economic assessment of district-scale solar energy integration in three residential districts under future climate conditions

This study evaluates the solar energy integration potential of three residential districts in Borlänge, Sweden; Riga, Latvia; and Amsterdam, Netherlands under present-day and future climate scenarios for 2050 and 2080. District-scale energy simulations were conducted using the Ci...

Metacognitive Training for Negative Symptoms (MCT-Minus) in schizophrenia: study protocol for a pragmatic randomized controlled trial

Abstract Background Negative symptoms are experienced by up to 60% of the individuals with schizophrenia and represent a stronger indicator of current and future functioning than positive symptoms. These symptoms respond poorly to pharmacological and existing psychosocial interve...

One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa

ABSTRACT: Acute pain in hospitalised patients is common, yet African data are scarce. We conducted a prospective point-prevalence study of hospitalised adult patients across Africa to determine acute pain prevalence and severity and investigate associations of pain with critical...