Center for Children

tiRNA-Pro-AGG-001 serves as a host-directed prognostic biomarker and therapeutical target for pediatric sepsis

Pediatric sepsis and septic shock remain major causes of mortality in Children, yet robust, mechanistically anchored biomarkers for severity stratification are limited. We profiled plasma tRNA-derived small RNAs (tsRNAs) in children with sepsis and septic shock, and validated can...

Genomic characterization of carbapenem-resistant organisms from pediatric patients with hematological malignancies and genomic comparison of infection versus intestinal colonizing strains

ABSTRACT This study aimed to characterize the species distribution, sequence types, and antimicrobial resistance mechanisms of carbapenem-resistant organisms (CROs) in pediatric patients with hematological malignancies, and to clarify the genomic relationship between clinical inf...

Management of Hip Instability in Spinal Muscular Atrophy in the Disease-Modifying Therapy Era: The “Late Autumn” or “Early Spring” of Neuro-Orthopedics?

Neuro-orthopedics is a field comprising knowledge and methods aimed at the diagnosis and treatment of secondary musculoskeletal disorders resulting from primary nervous system pathology. Historically, the greatest step in its development was associated with overcoming the consequ...

Acceptability and feasibility of implementing the I Can Problem Solve (ICPS) program among preschoolers in Chile: results of a pilot randomised controlled trial

Mental health disorders often begin early in life and are disproportionately prevalent among children in low-resource settings. School-based social-emotional learning (SEL) programs have shown promise in promoting cognitive and emotional skills in young children, yet few have bee...

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

OBJECTIVE: This study was undertaken to assess long-term efficacy, safety, and tolerability of adjunctive cenobamate in an open-label extension (OLE) of a randomized, double-blind, placebo-controlled, dose-response study (NCT04557085; YKP3089C035 [Study C035]) in Asian patients w...

Following the rules: which type 1 diabetes guidelines, protocols and recommendations are tertiary clinics in Australia following? A quantitative study

OBJECTIVES: This study characterises the use of type 1 diabetes (T1D) guidelines and protocols in Australian T1D clinics working with paediatric patients, and determines if management practices align with T1D-specific guidelines. METHODS: T1D clinic service leaders responded to a...

Less air pollution previously related to clean air and climate policies is linked to improved cognitive scores over time in NYC children

Prenatal and postnatal exposure to air pollution has been associated in multiple epidemiological studies with adverse neurodevelopmental outcomes in children, including in New York City cohorts. Studies are lacking on changes in associations between air quality and neurodevelopme...