Cell Technology (China)

Metabolic reprogramming for CAR-T cell therapy: advances and perspectives

Chimeric antigen receptor T cell (CAR-T) therapy has redefined the therapeutic landscape of hematological malignancies, yet its efficacy in solid tumors remains constrained by rapid functional attrition. Metabolic fitness serves as the primary arbiter of CAR-T cell fate, orchestr...

Artificial Intelligence in Trichoscopy: From Image Classification to Longitudinal Quantitative Hair Phenotyping - A Clinical-Technical Perspective and Validation Roadmap

Artificial intelligence (AI) in hair and scalp disorders has progressed from small proof-of-concept classifiers toward systems that quantify hair loss, stage androgenetic alopecia, assess alopecia areata severity, distinguish inflammatory scalp disease, and estimate phototrichogr...

Coordination‐Driven Pt(II)‐Ru(II) Heterometallacycles With Ultrastrong Cathodic Electrochemiluminescence and Guest‐Responsive Signal Amplification

ABSTRACT Coordination‐driven self‐assembly enables the integration of multiple functional elements within a single supramolecular architecture. By combining emissive chromophores, optimized electronic structures, and confined microenvironments, it provides an effective strategy f...

Decoupled Synthesis Pathway via Precursor Functionalization Stabilizes High‐Voltage Nickel‐Based Cathodes

ABSTRACT Nickel‐based layered cathodes are promising candidates for high‐performance, high‐energy lithium‐ion batteries, yet their high‐voltage application is jointly limited by synthesis‐inherited structural defects and an unstable lattice oxygen framework. Here, we show that bo...

Prognostic significance of adropin with Grace and Gensini scores for in-hospital outcomes in ST: elevation myocardial infarction patients

This prospective cohort study investigated the prognostic value of serum Adropin in patients with ST-segment elevation myocardial infarction (STEMI) and its incremental predictive utility beyond traditional GRACE and Gensini scores. A total of 508 participants were enrolled, incl...

Targeting a CDH1–TK1–dependent DNA Synthesis Pathway Overcomes Chemoresistance in Acute Myeloid Leukemia

ABSTRACT Relapsed and refractory acute myeloid leukemia (AML) remains difficult to treat, in part because leukemic cells adapt to nucleoside analogue‐induced replication stress. Here, we identify thymidine kinase 1 (TK1) as a functional contributor to chemotherapy resistance in A...

A Tumor-Microenvironment-Responsive Chemically MaskedIL-2 Prodrug Potentiates PD-1 Checkpoint Blockade andElicits Robust Antitumor Efficacy

Abstract Interleukin-2 (IL-2) is a potent mediator of T-cell activation with significant potential for cancer immunotherapy, yet its clinical utility is severely constrained by its narrow therapeutic window. Here we report a chemically masked IL-2 prodrug (Cm-proIL2) that enables...