CEA Paris-Saclay - Etablissement de Fontenay-aux-roses

MicroRNA 517a-3p suppresses α-synuclein fibril accumulation in human glioblastoma cells

Abstract Background Synucleinopathies are a group of neurodegenerative disorders characterized by the misfolding, aggregation, and accumulation of α-synuclein (α-syn) into oligomeric assemblies and amyloid inclusions. Alongside neurons, glial cells can internalize pathological α-...

The Enigma of Finnish and Sardinian Type 1 Diabetes Incidence: Where Population History Meets Genetics

Finland and Sardinia have very high incidences of autoimmune type 1 diabetes (T1D), particularly in children, far exceeding those of other European countries—an enigma that has persisted for some forty years. Genetics has so far had only the established T1D-predisposing variants...