CEA Paris-Saclay

Integrating Drug Physicochemistry and Hfq-Dependent Regulation of Ciprofloxacin Accumulation in Escherichia coli

Ciprofloxacin (CIP), an amphoteric fluoroquinolone, undergoes pH-dependent changes in protonation state that influence membrane permeability and intracellular accumulation. Here, we investigated how drug physicochemistry and bacterial regulatory pathways jointly determine CIP acc...

Paraneoplastic podocytopathies with nephrotic syndrome in solid cancers with C-Maf Inducing Protein expression

Abstract Background The main features of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) associated with solid cancer (paraneoplastic podocytopathy with nephrotic syndrome, PPNS) remain poorly described. Methods In this French retrospective study, we fo...

Resolving the LiFePO4 Battery State beyond Voltage-Based Diagnostics Using Surface-Scan MRI

Reliable assessment of state of charge (SoC) and state of health (SoH) in commercial batteries remains a major challenge because their closed architecture obscures the underlying electrochemical, structural, and thermal processes, while existing diagnostic methods often provide o...

Structure-activity relationship and membrane-targeting mechanisms of shikimate-related metabolites against Gram-positive and Gram-negative bacteria

AIMS: The rise of antibiotic-resistant bacteria has intensified the search for novel antimicrobials. In this context, shikimic acid is a versatile scaffold widely used as a precursor to bioactive compounds and drugs. This study screened the antimicrobial activity and underlying m...

Novel geometrical test of cosmological expansion from photometric data

In tomographic cosmic-shear observations, the Bernardeau, Nishimichi, Taruya (BNT) transform allows us to build weak lensing transformed maps for which the contribution from low-redshift lenses is nulled. As this transformation depends specifically on the expansion rate of the Un...

The Composite Spectrum of QSO Absorption Line Systems in DESI DR2

Abstract We present details regarding a composite spectrum of quasar (QSO) absorption line systems. In this composite spectrum, we identify more than 70 absorption lines and observe oxygen and hydrogen emission features at a higher signal-to-noise ratio than any previous study. A...

Emotional Responses (Intensity/Valence) Fulfill RDoC Criteria but Remain Excluded From Diagnostic Classifications of Mood Disorders

OBJECTIVES: Categorical classifications of depression, such as DSM-5 and ICD, are limited by high clinical heterogeneity, arbitrary diagnostic thresholds, and weak links to underlying pathophysiology. In line with the Research Domain Criteria (RDoC) framework, this article propos...

Immobilization of Alginate Microbeads With Whole‐Cells Expressing Nitrilase for Continuous Nicotinic Acid Production in Chip Millireactor

ABSTRACT The biocatalytic production of nicotinic acid using nitrilases has emerged as a promising alternative to conventional chemical synthesis, offering improved selectivity and environmental sustainability. In this study, we developed a continuous‐flow millireactor system emp...

Comprehensive profiling of brain dynamics during anesthesia across phylogeny

Abstract The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, ze...

Redefining Last Glacial Maximum environmental conditions in northeastern Brazil: pollen-based evidence of open and moist-adapted vegetation cover

Limited continuous continental records and complex climatic interactions hinder a comprehensive understanding of paleoclimatic and paleoenvironmental conditions during the Last Glacial Maximum (LGM) in the tropics. Adjacent to the currently semi-arid northeastern Brazil (NEB), a...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Irradiation Embrittlement in Grade-300 Steel Internals: A Comprehensive Description and Evaluation Approach

Water-cooled nuclear reactors are equipped with internal structural elements made of grade 300 steels, which are subject to embrittlement over their operational lifetime. More specifically, typical internal components are simultaneously exposed to neutron irradiation and pressuri...

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

While bioorthogonal click chemistry has transformed chemical biology, chelation‐assisted transition‐metal catalysis has emerged as a powerful yet still underexplored alternative tool for studying biological processes. This review provides a comprehensive overview of recent chelat...

Unprecedented In Vivo MRI Resolution of Basal Ganglia at 11.7 T

This case report describes 11.7-T in vivo human brain magnetic resonance imaging (MRI) of the basal ganglia in 2 healthy volunteers.

14,028 Nights with John Danziger under the veil of SN 1987A

This is a summary of the observations of the supernova SN 1987A conducted in infrared by John Danziger and myself from February 1987 until today. I recall the main results obtained in the past and present the latest results obtained recently with the JWST.

Sex-related variability of white-matter tracts is robust to tractography methodology

Abstract Diffusion tractography is the prominent in-vivo technique to study and investigate white-matter pathways in the human brain. While tractography is a powerful method, recent work suggests that different tractography methods can produce strikingly different representations...

14,028 Nights with John Danziger under the veil of SN 1987A

This is a summary of the observations of the supernova SN 1987A conducted in infrared by John Danziger and myself from February 1987 until today. I recall the main results obtained in the past and present the latest results obtained recently with the JWST.

Anti-thymocyte globulin triggers TNF-dependent cell death in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) accounts for one of the most aggressive hematological tumors associated with poor prognosis, notably for relapsed and refractory patients. Hence, an unmet medical need persists for T-ALL patients who fail to durably respond to conventio...

Unsupervised deep learning for limited-angle STEM-EDX tomography: application to 3D chemical analysis of phase-change memory devices

Abstract Energy-dispersive X-ray (EDX) tomography in scanning transmission electron microscopy (STEM) enables three-dimensional elemental mapping at the nanoscale. However, its application remains challenging when sample geometry severely restricts the accessible tilt range, and...

Introducing shrubs enhances the representation of high-latitude vegetation and carbon cycling in the ORCHIDEE land surface model

Arctic–Boreal terrestrial ecosystems are rapidly changing under amplified high-latitude warming, including widespread expansion of shrubs, with consequences for regional carbon and energy balances. Yet, high-latitude vegetation diversity and vegetation–climate interactions remain...