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Axillary right vein percutaneous ballooning in hemodialysis catheter replacement: A case report

Reliable vascular access remains a key point of hemodialysis therapy although each patient's journey through chronic kidney disease is unique. The 2019 Kidney Disease Outcomes Quality Initiative (KDOQI) vascular access guidelines introduced a patient-centered approach, emphasizin...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Disruption of the TDP-43/RILP axis impairs autophagic flux and stress granule homeostasis

Abstract TDP-43 has many functions, including the regulation of autophagy and stress granule dynamics, and mutations in TDP-43 are causative of amyotrophic lateral sclerosis (ALS). Among these, the G376D mutation is associated with TDP-43 cytoplasmic mislocalization and mitochond...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

Bad Blood: Navigating VTE Risk in Breast, Ovarian, and Endometrial Cancer

Cancer-associated thrombosis (CAT) is defined as venous or arterial thrombotic events occurring in patients with active malignancy or during anticancer treatment, most commonly presenting as venous thromboembolism and representing a leading cause of morbidity and mortality in onc...

Sustained seizure reduction, treatment simplification, and high retention with cenobamate: A 12‐month real‐world study in refractory and ultra‐refractory focal epilepsy

Abstract Objective To assess the 12‐month clinical impact of cenobamate (CNB) in adults with drug‐resistant focal epilepsy in clinical practice, exploring whether outcomes differed according to prior antiseizure medication (ASM) exposure. Methods This single‐center, retrospective...

Readmission to hospital after thoracic trauma: better safe than sorry! the predictive read score

Thoracic trauma accounts for approximately 10–15% of trauma admissions and contributes substantially to trauma-related morbidity and mortality. Readmission rates for thoracic trauma have not been investigated thus far; thus, the purpose of this retrospective study is to reduce pa...