Carilion Clinic

The Duration of Pavlik Harness Wear Following Successful Reduction of Dislocated Hips Does Not Play a Role in Determining Radiographic Dysplasia at 2 Years.

BACKGROUND: Though the Pavlik harness is often used to reduce dislocated hips in infants with developmental dysplasia of the hip (DDH), residual acetabular dysplasia may occur following reduction. It is unclear whether patient or treatment-related factors, including Pavlik wear d...

Utility of 18F-FDG PET-CT Scan in Patients With Staphylococcus aureus Bacteremia

Background: Staphylococcus aureus bacteremia is a common yet serious infection with high morbidity and mortality. This study evaluated 18F-FDG PET-CT scan in regards to improving 30- and 90-day mortality in patients with S. aureus bacteremia. Methods: We retrospectively identifie...

“A dicey situation:” asymptomatic hypertensive urgency caused by DICER1 mutation–derived cystic nephroma in a 12-month-old

Abstract Cystic nephroma (CN) in pediatric patients is a rare, benign, multi-lobular cystic mass often indicative of DICER1 tumor predisposition syndrome. This condition is caused by a germline mutation of the DICER1 gene and requires appropriate follow-up to monitor for other DI...

Optimizing Motor Skill Acquisition in Laparoscopic Surgery With Automated Gaze-Based Feedback

Gaze-based training has shown promise for laparoscopic surgery, but personalized gaze feedback to support skill acquisition remains underexplored. This study recruited 30 college students to practice the peg transfer task across two sessions using a prototype system delivering pe...

When Noise Gets into the Notes: Auditory Distraction Effects on Triage Documentation in a Simulated ED Waiting Room

Emergency department (ED) waiting rooms have complex soundscapes where nurses sometimes perform triage and documentation amid task-irrelevant sounds. This study examined whether auditory distraction affects documentation accuracy across noise types and interval patterns. Thirty-t...

Density dependence and evolvability limit adaptive therapy in non-small cell lung cancer mouse model

Abstract Using NSG mice grafted with H3122 non-small cell lung cancer cells, we compared outcomes from (1) continuous therapy with alectinib, (2) adaptive therapy where alectinib was cycled on and off based on a mouse’s tumor burden, and (3) no treatment. Adaptive therapy has pro...