Capital Institute of Pediatrics

Novel Compound Heterozygous CEP152 Variants Associated with Atypical Seckel Syndrome 5 in a Chinese Child: Functional Characterization of a Novel Splice-Site Variant and Expansion of the Genotype–Phenotype Spectrum

Background: Seckel syndrome (SCKL) is a rare autosomal-recessive inherited disorder characterized by intrauterine and postnatal growth restriction, microcephaly, “bird-like” facial dysmorphisms, and mild-to-moderate intellectual disability (ID). CEP152 is one of the known causati...

Outpatient versus telephone follow-up and blood pressure control in China: a longitudinal study in primary care

As the population ages, long-term standardized management of hypertension has become a critical task for primary healthcare systems. Telephone follow-up is widely used as a supplementary approach to outpatient care; however, its long-term effectiveness in real-world settings rema...

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

ABSTRACT STING agonists (e.g., cGAMP), which function as immunotherapeutic agents activating the stimulator of interferon genes (STING) pathway, hold promise for treating pediatric solid tumors including neuroblastoma. However, their clinical translation is hindered by limitation...

Normative values of hand grip and pinch strength in children and adolescents aged 3 to 17 years in Beijing and Tianjin Municipalities of China and their associations with body composition

Skeletal muscle plays major roles in metabolism, and it is important to assess the muscle function development in children during childhood. Hand grip and pinch strength are used as indicators of musculoskeletal function in children. The aim of this study was to establish normati...

Establishment of pediatric reference intervals for myocardial enzymes in Beijing using an indirect method

Abstract Background Pediatric myocardial enzyme reference intervals (RIs) are crucial for diagnosing myocardial injury in children, but China currently lacks pediatric-specific RIs for most cardiac biomarkers, relying instead on adult standards. This study aimed to establish pedi...

Body Composition–Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation

Traditional measures such as BMI do not fully capture obesity-related metabolic risks. Here, we examined DXA-derived body composition patterns in children (n = 11,238) using the discriminative dimensionality reduction tree algorithm, which was validated in an independent cohort (...

Quality assessment of primary health care for infants and young children in Hunan Province of China

Abstract Objective To comprehensively evaluate the service quality of primary health care (PHC) for children aged 0–3 years in healthcare facilities of China, and to identify strengths and existing gaps to provide evidence for optimizing regional child health service policies. Me...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...