Cangzhou Central Hospital

High-resolution magnetic resonance angiography for predicting short-term prognosis in young patients with atherosclerotic stroke: a mediation analysis based on middle cerebral artery plaque characteristics

Abstract Objective This study primarily evaluated the predictive value of middle cerebral artery (MCA) plaque characteristics, assessed by high-resolution magnetic resonance vessel wall imaging (HR-VWI), for 90-day prognosis in young patients with atherosclerotic ischemic stroke....

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

Efficacy and Safety of Crisugabalin for Inadequately Controlled Diabetic Peripheral Neuropathic Pain: A Randomized, Active‐Controlled, Phase 2 Trial

AIMS: Crisugabalin (HSK16149), a selective γ-aminobutyric acid (GABA) analog, has shown preliminary efficacy in controlling diabetic peripheral neuropathic pain (DPNP), but efficacy in patients with inadequate response to prior pregabalin treatment remains unknown. MATERIALS AND...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

Comparison of quantitative CT parameters acquired via the CT spine bone quantification system between L1 cortical and cancellous bone for predicting severity in male patients with chronic obstructive pulmonary disease: a retrospective study

Until present, data on the association between cortical bone changes in osteoporosis and severity of the condition of Chronic obstructive pulmonary disease (COPD) patients are lacking. This study aims to explore and compare the value of quantitative parameters of cortical and can...

Machine learning–random survival forest prediction model for predicting short-term recurrence after first-episode acute pancreatitis

Abstract Background This study aimed to construct and assess a machine learning–random survival forest prediction model for predicting short-term recurrence after first-episode acute pancreatitis (AP). Methods A total of 568 patients with AP admitted to Cangzhou Central Hospital...

Development of an explainable machine learning model for predicting six-month consciousness recovery in patients with prolonged disorders of consciousness

With advances in emergency care systems, the number of patients with prolonged disorders of consciousness (pDoC) has markedly increased. To optimize the allocation of healthcare resources and mitigate risks, the early and accurate identification of recovery potential in pDoC is e...

Factors associated with 30-day unplanned readmission after first-ever ischemic stroke: a retrospective cohort study in China

Unplanned readmission is an important post-stroke outcome, but clinically detailed data from Chinese cohorts remain limited. We evaluated the frequency of 30-day unplanned readmission after first-ever ischemic stroke and examined clinical factors associated with this outcome. We...

Ultrasound-guided stellate ganglion block enhances hemodynamic stability and postoperative recovery after laparoscopic myomectomy: a randomized controlled trial

To evaluate the effects of ultrasound-guided right stellate ganglion block (SGB) combined with propofol-based general anesthesia on perioperative hemodynamics, postoperative pain, recovery, and inflammatory stress responses in women undergoing laparoscopic myomectomy. In this sin...

AP-1-IL-1β signaling pathway on impulsive-like behavior and memory deficits in aged mice under tibial plateau fracture conditions

Tibial fracture surgery has attracted significant interest as a notable trigger for PND. Under external stimuli such as anesthesia and surgery, the transcription factor AP-1 regulates the abnormal expression of glutamatergic neurons via interleukin-1β (IL-1β), a mechanism closely...

Post-injury high-sensitivity C-reactive protein to lymphocyte ratio and nonunion risk in adult extremity fractures: evidence from a multicenter retrospective cohort

Early immuno-inflammatory response serves a critical role in the process of fracture healing, and both excessive and insufficient activation after injury may predict adverse outcomes. This study aimed to investigate the association between post-injury high-sensitivity C-reactive...