CancerCare Manitoba

ATF6 shapes PERK and IRE1 signaling dynamics during ER stress

Abstract The Unfolded Protein Response (UPR) is a conserved network of signaling pathways controlled by the Endoplasmic Reticulum (ER) anchored stress sensors IRE1, PERK and ATF6. The UPR’s primary function is to help cells manage and resolve ER stress. Compared with the well-cha...

Patient-physician sex concordance and real-world disparities in cancer treatment practices and outcomes in medical oncology

The impact of sex inequities in healthcare may be magnified in medical oncology, where patients and physicians often navigate life-limiting illnesses and intensive treatments. We examined the associations among patient-physician sex concordance, treatment practices, and cancer ou...